Jan Ernerudh1, Göran Berg, Jenny Mjösberg. 1. Division of Clinical Immunology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden. jan.ernerudh@lio.se
Abstract
PROBLEM: During pregnancy, the maternal immune system needs to adapt in order not to reject the semi-allogenic fetus. METHOD: In this review, we describe and discuss the role of regulatory T (Treg) cells in fetal tolerance. RESULTS: Treg cells constitute a T helper lineage that is derived from thymus (natural Treg cells) or is induced in the periphery (induced Treg cells). Treg cells are enriched at the fetal-maternal interface, showing a suppressive phenotype. In contrast, Treg cells are not increased in the circulation of pregnant women, and the suppressive capacity is similar to that in non-pregnant women. However, aberrations in Treg frequencies and functions, both systemically and in the uterus, may be involved in the complications of pregnancy. CONCLUSION: Treg cells seem to have distinguished roles locally versus systemically, based on their distribution and phenotype.
PROBLEM: During pregnancy, the maternal immune system needs to adapt in order not to reject the semi-allogenic fetus. METHOD: In this review, we describe and discuss the role of regulatory T (Treg) cells in fetal tolerance. RESULTS: Treg cells constitute a T helper lineage that is derived from thymus (natural Treg cells) or is induced in the periphery (induced Treg cells). Treg cells are enriched at the fetal-maternal interface, showing a suppressive phenotype. In contrast, Treg cells are not increased in the circulation of pregnant women, and the suppressive capacity is similar to that in non-pregnant women. However, aberrations in Treg frequencies and functions, both systemically and in the uterus, may be involved in the complications of pregnancy. CONCLUSION: Treg cells seem to have distinguished roles locally versus systemically, based on their distribution and phenotype.
Authors: A Varese; F Remes Lenicov; M Gonzalez Prinz; A Paletta; G Ernst; C Maeto; A Merlotti; J Sabatte; S Símula; M P Holgado; E Dantas; J Geffner; A Ceballos Journal: Mucosal Immunol Date: 2017-07-26 Impact factor: 7.313
Authors: JoonHo Lee; Roberto Romero; Yi Xu; Jezid Miranda; Wonsuk Yoo; Piya Chaemsaithong; Juan Pedro Kusanovic; Tinnakorn Chaiworapongsa; Adi L Tarca; Steven J Korzeniewski; Sonia S Hassan; Nandor Gabor Than; Bo Hyun Yoon; Chong Jai Kim Journal: Am J Reprod Immunol Date: 2013-08 Impact factor: 3.886