Literature DB >> 21725542

Efficient chemoenzymatic synthesis of sialyl Tn-antigens and derivatives.

Li Ding1, Hai Yu, Kam Lau, Yanhong Li, Saddam Muthana, Junru Wang, Xi Chen.   

Abstract

An N-terminal and C-terminal truncated recombinant α2-6-sialyltransferase cloned from Photobacterium sp. JH-ISH-224, Psp2,6ST(15-501)-His(6), was shown to be an efficient catalyst for one-pot three-enzyme synthesis of sialyl Tn (STn) antigens and derivatives containing natural and non-natural sialic acid forms. This journal is © The Royal Society of Chemistry 2011

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Year:  2011        PMID： 21725542      PMCID： PMC3201767          DOI： 10.1039/c1cc12732b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  31 in total

1.  Enhancement of the immunogenicity of synthetic carbohydrate vaccines by chemical modifications of STn antigen.

Authors:  Fan Yang; Xiu-Jing Zheng; Chang-Xin Huo; Yue Wang; Ye Zhang; Xin-Shan Ye
Journal:  ACS Chem Biol       Date:  2011-01-07       Impact factor: 5.100

2.  A multifunctional Pasteurella multocida sialyltransferase: a powerful tool for the synthesis of sialoside libraries.

Authors:  Hai Yu; Harshal Chokhawala; Rebekah Karpel; Hui Yu; Bingyuan Wu; Jianbo Zhang; Yingxin Zhang; Qiang Jia; Xi Chen
Journal:  J Am Chem Soc       Date:  2005-12-21       Impact factor: 15.419

Review 3.  Possible functions of tumor-associated carbohydrate antigens.

Authors:  S Hakomori
Journal:  Curr Opin Immunol       Date:  1991-10       Impact factor: 7.486

4.  Serum sialyl Tn as an independent predictor of poor prognosis in patients with epithelial ovarian cancer.

Authors:  H Kobayashi; T Terao; Y Kawashima
Journal:  J Clin Oncol       Date:  1992-01       Impact factor: 44.544

5.  Predictive factors for preoperative serum levels of sialy Lewis(x), sialyl Lewis(a) and sialyl Tn antigens in gastric cancer patients.

Authors:  Tohru Nakagoe; Terumitsu Sawai; Takashi Tsuji; Masa-Aki Jibiki; Atsushi Nanashima; Hiroyuki Yamaguchi; Toru Yasutake; Hiroyoshi Ayabe; Kokichi Arisawa; Hiroshi Ishikawa
Journal:  Anticancer Res       Date:  2002 Jan-Feb       Impact factor: 2.480

Review 6.  Vaccination with Theratope (STn-KLH) as treatment for breast cancer.

Authors:  Leona A Holmberg; Brenda M Sandmaier
Journal:  Expert Rev Vaccines       Date:  2004-12       Impact factor: 5.217

7.  Unusually high concentrations of sialic acids on the surface of vascular endothelia.

Authors:  G V Born; W Palinski
Journal:  Br J Exp Pathol       Date:  1985-10

8.  Crystal structure of Vibrionaceae Photobacterium sp. JT-ISH-224 alpha2,6-sialyltransferase in a ternary complex with donor product CMP and acceptor substrate lactose: catalytic mechanism and substrate recognition.

Authors:  Yoshimitsu Kakuta; Nozomu Okino; Hitomi Kajiwara; Masako Ichikawa; Yoshimitsu Takakura; Makoto Ito; Takeshi Yamamoto
Journal:  Glycobiology       Date:  2007-10-25       Impact factor: 4.313

9.  An alpha2,6-sialyltransferase cloned from Photobacterium leiognathi strain JT-SHIZ-119 shows both sialyltransferase and neuraminidase activity.

Authors:  Toshiki Mine; Sakurako Katayama; Hitomi Kajiwara; Masako Tsunashima; Hiroshi Tsukamoto; Yoshimitsu Takakura; Takeshi Yamamoto
Journal:  Glycobiology       Date:  2009-09-30       Impact factor: 4.313

10.  Efficient chemoenzymatic synthesis of biotinylated human serum albumin-sialoglycoside conjugates containing O-acetylated sialic acids.

Authors:  Hai Yu; Harshal A Chokhawala; Ajit Varki; Xi Chen
Journal:  Org Biomol Chem       Date:  2007-06-27       Impact factor: 3.876
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  13 in total

Review 1.  Glycosyltransferase engineering for carbohydrate synthesis.

Authors:  John B McArthur; Xi Chen
Journal:  Biochem Soc Trans       Date:  2016-02       Impact factor: 5.407

2.  Converting Pasteurella multocidaα2-3-sialyltransferase 1 (PmST1) to a regioselective α2-6-sialyltransferase by saturation mutagenesis and regioselective screening.

Authors:  John B McArthur; Hai Yu; Jie Zeng; Xi Chen
Journal:  Org Biomol Chem       Date:  2017-01-30       Impact factor: 3.876

3.  Membrane-tethered mucin-like polypeptides sterically inhibit binding and slow fusion kinetics of influenza A virus.

Authors:  Corleone S Delaveris; Elizabeth R Webster; Steven M Banik; Steven G Boxer; Carolyn R Bertozzi
Journal:  Proc Natl Acad Sci U S A       Date:  2020-05-26       Impact factor: 11.205

4.  Cross-comparison of protein recognition of sialic acid diversity on two novel sialoglycan microarrays.

Authors:  Vered Padler-Karavani; Xuezheng Song; Hai Yu; Nancy Hurtado-Ziola; Shengshu Huang; Saddam Muthana; Harshal A Chokhawala; Jiansong Cheng; Andrea Verhagen; Martijn A Langereis; Ralf Kleene; Melitta Schachner; Raoul J de Groot; Yi Lasanajak; Haruo Matsuda; Richard Schwab; Xi Chen; David F Smith; Richard D Cummings; Ajit Varki
Journal:  J Biol Chem       Date:  2012-05-01       Impact factor: 5.157

5.  α2-6-Neosialidase: A Sialyltransferase Mutant as a Sialyl Linkage-Specific Sialidase.

Authors:  John B McArthur; Hai Yu; Nova Tasnima; Christie M Lee; Andrew J Fisher; Xi Chen
Journal:  ACS Chem Biol       Date:  2018-03-28       Impact factor: 5.100

6.  One-pot multi-enzyme (OPME) chemoenzymatic synthesis of sialyl-Tn-MUC1 and sialyl-T-MUC1 glycopeptides containing natural or non-natural sialic acid.

Authors:  Hamed Malekan; Gabriel Fung; Vireak Thon; Zahra Khedri; Hai Yu; Jingyao Qu; Yanhong Li; Li Ding; Kit S Lam; Xi Chen
Journal:  Bioorg Med Chem       Date:  2013-03-07       Impact factor: 3.641

7.  One-pot multienzyme (OPME) systems for chemoenzymatic synthesis of carbohydrates.

Authors:  Hai Yu; Xi Chen
Journal:  Org Biomol Chem       Date:  2016-03-14       Impact factor: 3.876

8.  Chemoenzymatic synthesis of Neu5Ac9NAc-containing α2-3- and α2-6-linked sialosides and their use for sialidase substrate specificity studies.

Authors:  Wanqing Li; An Xiao; Yanhong Li; Hai Yu; Xi Chen
Journal:  Carbohydr Res       Date:  2017-09-18       Impact factor: 2.104

9.  A Diazido Mannose Analogue as a Chemoenzymatic Synthon for Synthesizing Di-N-acetyllegionaminic Acid-Containing Glycosides.

Authors:  Abhishek Santra; An Xiao; Hai Yu; Wanqing Li; Yanhong Li; Linh Ngo; John B McArthur; Xi Chen
Journal:  Angew Chem Int Ed Engl       Date:  2018-02-14       Impact factor: 15.336

10.  A Photobacterium sp. α2-6-sialyltransferase (Psp2,6ST) mutant with an increased expression level and improved activities in sialylating Tn antigens.

Authors:  Li Ding; Chao Zhao; Jingyao Qu; Yanhong Li; Go Sugiarto; Hai Yu; Junru Wang; Xi Chen
Journal:  Carbohydr Res       Date:  2014-12-23       Impact factor: 2.975
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