| Literature DB >> 21724410 |
Daniela Cipolletta1, Dmitriy Kolodin, Christophe Benoist, Diane Mathis.
Abstract
Foxp3+CD4+ regulatory T (T(reg)) cells are a key population in controlling the immune response. Recently, their roles have been expanded to broader, non-immune, contexts, in particular the metabolic consequences downstream of obesity-induced inflammation, e.g. type-2 diabetes and cardiovascular disease. This review highlights the major innate and adaptive immune cell subsets contributing to adipose-tissue inflammation, the key role played by fat-resident T(regs), and the potential of T(reg)-based therapies for treatment of the metabolic syndrome.Entities:
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Year: 2011 PMID： 21724410 DOI： 10.1016/j.smim.2011.06.002
Source DB: PubMed Journal: Semin Immunol ISSN： 1044-5323 Impact factor: 11.130