Literature DB >> 2172437

Binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors.

M R Shalaby1, A Sundan, H Loetscher, M Brockhaus, W Lesslauer, T Espevik.   

Abstract

The present study was undertaken to further characterize the interaction of monoclonal antibodies (mAbs) against tumor necrosis factor (TNF) receptors with different targets, and to assess their ability to influence TNF effects on U937 and human endothelial cell (HEC) functions. Actions of recombinant TNF-alpha on U937 and HEC were effectively inhibited by Htr-5 and Utr-1, and to a greater extent by a combination of both mAbs. These observations indicate that TNF interaction with antigenically different components of membrane receptors (p55 and p75) represents a crucial step in transduction of signals for TNF toxicity against U937 and TNF activation of HEC functions.

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Year:  1990        PMID： 2172437      PMCID： PMC2188665          DOI： 10.1084/jem.172.5.1517

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  12 in total

Review 1.  The role of cachectin/TNF in endotoxic shock and cachexia.

Authors:  A Cerami; B Beutler
Journal:  Immunol Today       Date:  1988-01

2.  Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin.

Authors:  D Pennica; G E Nedwin; J S Hayflick; P H Seeburg; R Derynck; M A Palladino; W J Kohr; B B Aggarwal; D V Goeddel
Journal:  Nature       Date:  1984 Dec 20-1985 Jan 2       Impact factor: 49.962

3.  Receptor binding and activation of polymorphonuclear neutrophils by tumor necrosis factor-alpha.

Authors:  M R Shalaby; M A Palladino; S E Hirabayashi; T E Eessalu; G D Lewis; H M Shepard; B B Aggarwal
Journal:  J Leukoc Biol       Date:  1987-03       Impact factor: 4.962

4.  Cytokine regulation of interleukin 6 production by human endothelial cells.

Authors:  M R Shalaby; A Waage; T Espevik
Journal:  Cell Immunol       Date:  1989-07       Impact factor: 4.868

5.  Molecular cloning and expression of a receptor for human tumor necrosis factor.

Authors:  T J Schall; M Lewis; K J Koller; A Lee; G C Rice; G H Wong; T Gatanaga; G A Granger; R Lentz; H Raab
Journal:  Cell       Date:  1990-04-20       Impact factor: 41.582

6.  Identification of two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies.

Authors:  M Brockhaus; H J Schoenfeld; E J Schlaeger; W Hunziker; W Lesslauer; H Loetscher
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

7.  A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins.

Authors:  C A Smith; T Davis; D Anderson; L Solam; M P Beckmann; R Jerzy; S K Dower; D Cosman; R G Goodwin
Journal:  Science       Date:  1990-05-25       Impact factor: 47.728

8.  Two different cell types have different major receptors for human tumor necrosis factor (TNF alpha).

Authors:  H P Hohmann; R Remy; M Brockhaus; A P van Loon
Journal:  J Biol Chem       Date:  1989-09-05       Impact factor: 5.157

9.  Factors influencing endothelial cell proliferation in vitro.

Authors:  R T Wall; L A Harker; L J Quadracci; G E Striker
Journal:  J Cell Physiol       Date:  1978-08       Impact factor: 6.384

10.  Characterization of binding and biological effects of monoclonal antibodies against a human tumor necrosis factor receptor.

Authors:  T Espevik; M Brockhaus; H Loetscher; U Nonstad; R Shalaby
Journal:  J Exp Med       Date:  1990-02-01       Impact factor: 14.307
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  28 in total

Review 1.  Tumor necrosis factor-α signaling in macrophages.

Authors:  Narayanan Parameswaran; Sonika Patial
Journal:  Crit Rev Eukaryot Gene Expr       Date:  2010       Impact factor: 1.807

2.  Predominant activation of MAP kinases and pro-destructive/pro-inflammatory features by TNF alpha in early-passage synovial fibroblasts via TNF receptor-1: failure of p38 inhibition to suppress matrix metalloproteinase-1 in rheumatoid arthritis.

Authors:  Elke Kunisch; Muktheshwar Gandesiri; Reneé Fuhrmann; Andreas Roth; Rando Winter; Raimund W Kinne
Journal:  Ann Rheum Dis       Date:  2007-01-12       Impact factor: 19.103

3.  Fluorogen activating proteins in flow cytometry for the study of surface molecules and receptors.

Authors:  Matthew J Saunders; Christopher Szent-Gyorgyi; Gregory W Fisher; Jonathan W Jarvik; Marcel P Bruchez; Alan S Waggoner
Journal:  Methods       Date:  2012-02-16       Impact factor: 3.608

4.  The PML/RARalpha fusion protein inhibits tumor necrosis factor-alpha-induced apoptosis in U937 cells and acute promyelocytic leukemia blasts.

Authors:  U Testa; F Grignani; P Samoggia; C Zanetti; R Riccioni; F Lo Coco; D Diverio; N Felli; C G Passerini; M Grell; P G Pelicci; C Peschle
Journal:  J Clin Invest       Date:  1998-05-15       Impact factor: 14.808

5.  Tumor necrosis factor alpha (TNF-alpha) receptor-II is required for TNF-alpha-induced leukocyte-endothelial interaction in vivo.

Authors:  Unni M Chandrasekharan; Maria Siemionow; Murat Unsal; Lin Yang; Earl Poptic; Justin Bohn; Kagan Ozer; Zhongmin Zhou; Philip H Howe; Marc Penn; Paul E DiCorleto
Journal:  Blood       Date:  2006-10-26       Impact factor: 22.113

6.  Tumor necrosis factor alpha inhibits entry of human immunodeficiency virus type 1 into primary human macrophages: a selective role for the 75-kilodalton receptor.

Authors:  G Herbein; L J Montaner; S Gordon
Journal:  J Virol       Date:  1996-11       Impact factor: 5.103

7.  Isotype-specific regulation of MHC class II gene expression in human monocytes by exogenous and endogenous tumor necrosis factor.

Authors:  M Jasiński; J Wieckiewicz; I Ruggiero; A Pituch-Noworolska; M Zembala
Journal:  J Clin Immunol       Date:  1995-07       Impact factor: 8.317

8.  Tumor necrosis factor activates human endothelial cells through the p55 tumor necrosis factor receptor but the p75 receptor contributes to activation at low tumor necrosis factor concentration.

Authors:  M R Slowik; L G De Luca; W Fiers; J S Pober
Journal:  Am J Pathol       Date:  1993-12       Impact factor: 4.307

Review 9.  Understanding cytokine and growth factor receptor activation mechanisms.

Authors:  Mariya Atanasova; Adrian Whitty
Journal:  Crit Rev Biochem Mol Biol       Date:  2012-10-09       Impact factor: 8.250

10.  Disparate localization of 55-kd and 75-kd tumor necrosis factor receptors in human endothelial cells.

Authors:  J R Bradley; S Thiru; J S Pober
Journal:  Am J Pathol       Date:  1995-01       Impact factor: 4.307
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