| Literature DB >> 21723726 |
Tetsuta Oshitari1, Yuji Okuyama, Yoshiki Miyata, Hiroshi Kosano, Hideyo Takahashi, Hideaki Natsugari.
Abstract
A divergent synthesis of nobiletin metabolites was developed through highly oxygenated acetophenone derivative. We used commercially available methyl 3,4,5-trimethoxybenzoate as a starting material for concise preparation of the key intermediate, 2'-hydroxy-3',4',5',6'-tetramethoxyacetophenone (I). These metabolites showed strong inhibitory activity against matrix metalloproteinase-9 production in human lens epithelial cells.Entities:
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Year: 2011 PMID： 21723726 DOI： 10.1016/j.bmcl.2011.05.121
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823