OBJECTIVE: To study white matter integrity with diffusion tensor imaging in adolescents with prenatal cocaine exposure, tobacco exposure, or both. STUDY DESIGN: Subjects included 20 adolescents with prenatal cocaine exposure (15 with tobacco exposure) and 20 non-cocaine-exposed subjects (8 with tobacco exposure). Diffusion tensor imaging measures were assessed in 5 subregions of the corpus callosum. The Sensation Seeking Scale for Children was administered to evaluate behavioral inhibition. RESULTS: No significant differences were found between the cocaine-exposed and non-cocaine-exposed groups in each subregion of the corpus callosum on measures of fractional anisotropy (FA) and mean diffusivity, although the cocaine-exposed group showed a trend (P = .06) toward higher FA in projections to the supplementary motor area and premotor cortex. Prenatal tobacco exposure was associated with decreased FA in the supplementary motor area and premotor cortex projections after adjustment for relevant co-variates (P = .03). Decreased FA was related to more sensation seeking in the adolescents who were prenatally exposed to tobacco. CONCLUSION: Prenatal tobacco exposure could affect white matter integrity, which is related to sensation seeking in adolescents. Developmental neurotoxins might have differential influences on white matter maturation in adolescence.
OBJECTIVE: To study white matter integrity with diffusion tensor imaging in adolescents with prenatal cocaine exposure, tobacco exposure, or both. STUDY DESIGN: Subjects included 20 adolescents with prenatal cocaine exposure (15 with tobacco exposure) and 20 non-cocaine-exposed subjects (8 with tobacco exposure). Diffusion tensor imaging measures were assessed in 5 subregions of the corpus callosum. The Sensation Seeking Scale for Children was administered to evaluate behavioral inhibition. RESULTS: No significant differences were found between the cocaine-exposed and non-cocaine-exposed groups in each subregion of the corpus callosum on measures of fractional anisotropy (FA) and mean diffusivity, although the cocaine-exposed group showed a trend (P = .06) toward higher FA in projections to the supplementary motor area and premotor cortex. Prenatal tobacco exposure was associated with decreased FA in the supplementary motor area and premotor cortex projections after adjustment for relevant co-variates (P = .03). Decreased FA was related to more sensation seeking in the adolescents who were prenatally exposed to tobacco. CONCLUSION: Prenatal tobacco exposure could affect white matter integrity, which is related to sensation seeking in adolescents. Developmental neurotoxins might have differential influences on white matter maturation in adolescence.
Authors: Arthur L Brody; Mark A Mandelkern; Murray E Jarvik; Grace S Lee; Erlyn C Smith; Joe C Huang; Robert G Bota; George Bartzokis; Edythe D London Journal: Biol Psychiatry Date: 2004-01-01 Impact factor: 13.382
Authors: Stephen M Smith; Mark Jenkinson; Mark W Woolrich; Christian F Beckmann; Timothy E J Behrens; Heidi Johansen-Berg; Peter R Bannister; Marilena De Luca; Ivana Drobnjak; David E Flitney; Rami K Niazy; James Saunders; John Vickers; Yongyue Zhang; Nicola De Stefano; J Michael Brady; Paul M Matthews Journal: Neuroimage Date: 2004 Impact factor: 6.556
Authors: Charles R Bauer; John C Langer; Seetha Shankaran; Henrietta S Bada; Barry Lester; Linda L Wright; Heidi Krause-Steinrauf; Vincent L Smeriglio; Loretta P Finnegan; Penelope L Maza; Joel Verter Journal: Arch Pediatr Adolesc Med Date: 2005-09
Authors: Kristen P Morie; Sarah W Yip; Zu Wei Zhai; Jiansong Xu; Kristen R Hamilton; Rajita Sinha; Linda C Mayes; Marc N Potenza Journal: Drug Alcohol Depend Date: 2017-02-28 Impact factor: 4.492
Authors: Fleur L Warton; Paul A Taylor; Christopher M R Warton; Christopher D Molteno; Pia Wintermark; Nadine M Lindinger; Lilla Zöllei; Andre van der Kouwe; Joseph L Jacobson; Sandra W Jacobson; Ernesta M Meintjes Journal: Metab Brain Dis Date: 2017-10-23 Impact factor: 3.584
Authors: Sonia Minnes; Lynn T Singer; Meeyoung O Min; Adelaide M Lang; Aya Ben-Harush; Elizabeth Short; Miaoping Wu Journal: J Youth Adolesc Date: 2013-02-20
Authors: Nurunisa Akyuz; Minal V Kekatpure; Jie Liu; Stephen J Sheinkopf; Brian T Quinn; Meenakshi D Lala; David Kennedy; Nikos Makris; Barry M Lester; Barry E Kosofsky Journal: Dev Neurosci Date: 2014-07-01 Impact factor: 2.984