OBJECTIVES: Pseudoxanthoma elasticum (PXE) is an inherited metabolic disease characterized by elastic fiber fragmentation and calcification in the cutaneous, ophthalmologic, and vascular tissues. Cardiovascular manifestations such as peripheral arterial disease (PAD) are frequent in PXE. Because of the changes in the elastic properties and medial calcification of the arterial wall in PXE, the impact of the arterial remodeling on the ankle brachial index (ABI), a well-established diagnostic method for the detection and follow-up of PAD, remains to be determined in this disease. METHODS: This was a cross-sectional, comparative, open study, which took place at the PXE Consultation Center, University Hospital of Angers. The subjects were 53 patients (mean age, 49 ± 14 years; 35 females) with PXE clinically proven on the basis of established criteria (skin changes, angioid streaks, and skin biopsy). The ABI at rest, symptoms of intermittent claudication (IC), carotid intima-media thickness (IMT), carotid-femoral pulse wave velocity (c-f PWV), compliance (CC), and β stiffness index were measured in a single-center cohort. RESULTS: Forty-five percent of the PXE patients had an ABI ≤0.90, but only one patient had an ABI >1.40. IC was found in 23% of the patients with an ABI ≤0.90. There were no significant differences between the patients with a low and normal ABI in terms of IMT (P = .566) or β stiffness index (P = .194), but differences were significant for c-f PWV (P = .010) and CC (P = .011). Adjusted multivariate linear regression for the Framingham-Laurier score showed that patients with a low ABI had less compliant carotid arteries (B = 0.318, P = .039). CONCLUSIONS: PAD detected by a low ABI is very frequent in PXE, although with limited prevalence of symptomatic claudication. Unexpectedly, ABI was low in such calcifying PAD and associated with lower CC, independently of atherosclerosis risk factors. These findings demonstrate that PXE represents a unique monogenic model of PAD in which the specific arterial wall remodeling could change the diagnostic value of the ABI to detect PAD.
OBJECTIVES: Pseudoxanthoma elasticum (PXE) is an inherited metabolic disease characterized by elastic fiber fragmentation and calcification in the cutaneous, ophthalmologic, and vascular tissues. Cardiovascular manifestations such as peripheral arterial disease (PAD) are frequent in PXE. Because of the changes in the elastic properties and medial calcification of the arterial wall in PXE, the impact of the arterial remodeling on the ankle brachial index (ABI), a well-established diagnostic method for the detection and follow-up of PAD, remains to be determined in this disease. METHODS: This was a cross-sectional, comparative, open study, which took place at the PXE Consultation Center, University Hospital of Angers. The subjects were 53 patients (mean age, 49 ± 14 years; 35 females) with PXE clinically proven on the basis of established criteria (skin changes, angioid streaks, and skin biopsy). The ABI at rest, symptoms of intermittent claudication (IC), carotid intima-media thickness (IMT), carotid-femoral pulse wave velocity (c-f PWV), compliance (CC), and β stiffness index were measured in a single-center cohort. RESULTS: Forty-five percent of the PXE patients had an ABI ≤0.90, but only one patient had an ABI >1.40. IC was found in 23% of the patients with an ABI ≤0.90. There were no significant differences between the patients with a low and normal ABI in terms of IMT (P = .566) or β stiffness index (P = .194), but differences were significant for c-f PWV (P = .010) and CC (P = .011). Adjusted multivariate linear regression for the Framingham-Laurier score showed that patients with a low ABI had less compliant carotid arteries (B = 0.318, P = .039). CONCLUSIONS: PAD detected by a low ABI is very frequent in PXE, although with limited prevalence of symptomatic claudication. Unexpectedly, ABI was low in such calcifying PAD and associated with lower CC, independently of atherosclerosis risk factors. These findings demonstrate that PXE represents a unique monogenic model of PAD in which the specific arterial wall remodeling could change the diagnostic value of the ABI to detect PAD.
Authors: Olga von Beckerath; Jochen Gaa; Christoph Winkler von Mohrenfels; Nicolas von Beckerath Journal: Circulation Date: 2008-07-01 Impact factor: 29.690
Authors: Victor Aboyans; Michael H Criqui; Robyn L McClelland; Matthew A Allison; Mary McGrae McDermott; David C Goff; Teri A Manolio Journal: J Vasc Surg Date: 2007-02 Impact factor: 4.268
Authors: Victor Aboyans; Elena Ho; Julie O Denenberg; Lindsey A Ho; Loki Natarajan; Michael H Criqui Journal: J Vasc Surg Date: 2008-08-09 Impact factor: 4.268
Authors: M Emoto; Y Nishizawa; T Kawagishi; K Maekawa; Y Hiura; H Kanda; K Izumotani; T Shoji; E Ishimura; M Inaba; Y Okuno; H Morii Journal: Diabetes Care Date: 1998-07 Impact factor: 19.112
Authors: Gilles Kauffenstein; A Pizard; Y Le Corre; E Vessières; L Grimaud; B Toutain; C Labat; Y Mauras; T G Gorgels; A A Bergen; O Le Saux; P Lacolley; G Lefthériotis; D Henrion; L Martin Journal: Arterioscler Thromb Vasc Biol Date: 2014-03-27 Impact factor: 8.311
Authors: M Guérin-Moreau; G Leftheriotis; Y Le Corre; M Etienne; R Amode; J F Hamel; A Croué; O Le Saux; L Machet; L Martin Journal: Br J Dermatol Date: 2013-12 Impact factor: 9.302
Authors: Imran N Mungrue; Peng Zhao; Yucheng Yao; Haijin Meng; Christoph Rau; Jocelyn V Havel; Theo G M F Gorgels; Arthur A B Bergen; W Robb MacLellan; Thomas A Drake; Kristina I Boström; Aldons J Lusis Journal: Arterioscler Thromb Vasc Biol Date: 2011-10-06 Impact factor: 8.311
Authors: Sebastian Gorgonius Passon; Viviane Küllmar; Anna Katharina Blatzheim; Kristin Solveig Pausewang; Max Jonathan Stumpf; Doris Hendig; Martin Gliem; Simon Pingel; Robert Schueler; Dirk Skowasch; Najib Schahab; Georg Nickenig; Christian Alexander Schaefer Journal: Intractable Rare Dis Res Date: 2018-02
Authors: Georges Lefthériotis; Loukman Omarjee; Olivier Le Saux; Daniel Henrion; Pierre Abraham; Fabrice Prunier; Serge Willoteaux; Ludovic Martin Journal: Front Genet Date: 2013-02-12 Impact factor: 4.599
Authors: Olivier Le Saux; Ludovic Martin; Zouhair Aherrahrou; Georges Leftheriotis; András Váradi; Christopher N Brampton Journal: Front Genet Date: 2012-12-12 Impact factor: 4.599
Authors: Fabrice Prunier; Gwenola Terrien; Yannick Le Corre; Ailea L Y Apana; Loïc Bière; Gilles Kauffenstein; Alain Furber; Arthur A B Bergen; Theo G M F Gorgels; Olivier Le Saux; Georges Leftheriotis; Ludovic Martin Journal: PLoS One Date: 2013-07-23 Impact factor: 3.240