Literature DB >> 2172172

Suppressive effects of intracellular glutathione on hydroxyl radical production induced by tumor necrosis factor.

N Yamauchi1, N Watanabe, H Kuriyama, H Neda, M Maeda, T Himeno, Y Tsuji, Y Niitsu.   

Abstract

Protective effects of intracellular glutathione (GSH) against the cytotoxicity of human recombinant tumor necrosis factor (TNF) were investigated. Three tumor cell lines (L-M, B-16, HeLa) were used as target cells. Exposure of these cells to buthionine sulfoximine (BSO) or diethyl maleate (DEM) resulted in the depletion of intracellular GSH content to 5.2-43.0% of control values and enhancement of their susceptibility to TNF cytotoxicity. The hydroxyl radical production in L-M cells stimulated by TNF was increased by treatment with BSO or DEM. These results are consistent with the suggestion that intracellular GSH exerts its protective function against the cytocidal effect of TNF by inhibiting the hydroxyl radical production stimulated by TNF.

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Year:  1990        PMID： 2172172     DOI： 10.1002/ijc.2910460522

Source DB:  PubMed          Journal:  Int J Cancer        ISSN： 0020-7136            Impact factor:   7.396


  8 in total

1.  Glutathione and the rate of cellular proliferation determine tumour cell sensitivity to tumour necrosis factor in vivo.

Authors:  E Obrador; J Navarro; J Mompo; M Asensi; J A Pellicer; J M Estrela
Journal:  Biochem J       Date:  1997-07-01       Impact factor: 3.857

2.  Human hsp27, Drosophila hsp27 and human alphaB-crystallin expression-mediated increase in glutathione is essential for the protective activity of these proteins against TNFalpha-induced cell death.

Authors:  P Mehlen; C Kretz-Remy; X Préville; A P Arrigo
Journal:  EMBO J       Date:  1996-06-03       Impact factor: 11.598

3.  The role of glucagon-like peptide-2 on apoptosis, cell proliferation, and oxidant-antioxidant system at a mouse model of intestinal injury induced by tumor necrosis factor-alpha/actinomycin D.

Authors:  Pelin Arda-Pirincci; Sehnaz Bolkent
Journal:  Mol Cell Biochem       Date:  2010-12-14       Impact factor: 3.396

4.  Enhancement of lysosomal enzyme activity by recombinant human tumor necrosis factor and its role in tumor cell killing in vitro.

Authors:  N Watanabe; N Yamauchi; H Neda; M Maeda; Y Tsuji; T Okamoto; S Akiyama; H Sasaki; N Tsuji; Y Niitsu
Journal:  Jpn J Cancer Res       Date:  1992-06

5.  Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

Authors:  K Schulze-Osthoff; R Beyaert; V Vandevoorde; G Haegeman; W Fiers
Journal:  EMBO J       Date:  1993-08       Impact factor: 11.598

6.  Reversal of tumor necrosis factor resistance in tumor cells by adriamycin via suppression of intracellular resistance factors.

Authors:  N Watanabe; T Okamoto; N Tsuji; H Sasaki; S Akiyama; D Kobayashi; T Sato; N Yamauchi; Y Niitsu
Journal:  Jpn J Cancer Res       Date:  1995-04

7.  Lysosome labilizers potentiate the antitumor effects of tumor necrosis factor-alpha.

Authors:  T Masegi; A Kato; K Kitai; M Fukuoka; K Soma; Y Ichikawa; S Nakamura; N Watanabe; Y Niitsu
Journal:  Jpn J Cancer Res       Date:  1993-04

8.  Mechanism of synergistic cytotoxic effect between tumor necrosis factor and hyperthermia.

Authors:  N Yamauchi; N Watanabe; M Maeda; T Okamoto; H Sasaki; N Tsuji; Y Tsuji; H Umeno; S Akiyama; Y Niitsu
Journal:  Jpn J Cancer Res       Date:  1992-05
  8 in total

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