OBJECTIVES: Using cardiac magnetic resonance imaging (MRI) we tested the diagnostic value of various markers for amyloid infiltration. METHODS: We performed MRI at 1.5 T in 36 consecutive patients with cardiac amyloidosis and 48 healthy volunteers. The protocol included cine imaging, T2-weighted spin echo, T1-weighted spin echo before and early after contrast and late gadolinium enhancement. We compared the frequency of abnormalities and their relation to mortality. RESULTS: Median follow-up was 31 months. Twenty-three patients died. Mean left ventricular (LV) mass was 205 ± 70 g. LV ejection fraction (EF) was 55 ± 12%. T2 ratio was 1.5 ± 0.4. 33/36 patients had pericardial and 22/36 had pleural effusions. All but two had heterogeneous late enhancement. Surviving patients did not differ from those who had died with regard to gender, LV mass or volume. Surviving patients had a significantly higher LVEF (60.4 ± 9.9% vs. 51.6 ± 11.5%; p = 0.03). The deceased patients had a lower T2 ratio than those who survived (1.38 ± 0.42 vs. 1.76 ± 0.17; p = 0.005). Low T2 was associated with shorter survival (Chi-squared 11.3; p < 0.001). Cox regression analysis confirmed T2 ratio < 1.5 as the only independent predictors for survival. CONCLUSION: Cardiac amyloidosis is associated with hypointense signal on T2-weighted images. A lower T2 ratio was independently associated with shortened survival.
OBJECTIVES: Using cardiac magnetic resonance imaging (MRI) we tested the diagnostic value of various markers for amyloid infiltration. METHODS: We performed MRI at 1.5 T in 36 consecutive patients with cardiac amyloidosis and 48 healthy volunteers. The protocol included cine imaging, T2-weighted spin echo, T1-weighted spin echo before and early after contrast and late gadolinium enhancement. We compared the frequency of abnormalities and their relation to mortality. RESULTS: Median follow-up was 31 months. Twenty-three patients died. Mean left ventricular (LV) mass was 205 ± 70 g. LV ejection fraction (EF) was 55 ± 12%. T2 ratio was 1.5 ± 0.4. 33/36 patients had pericardial and 22/36 had pleural effusions. All but two had heterogeneous late enhancement. Surviving patients did not differ from those who had died with regard to gender, LV mass or volume. Surviving patients had a significantly higher LVEF (60.4 ± 9.9% vs. 51.6 ± 11.5%; p = 0.03). The deceased patients had a lower T2 ratio than those who survived (1.38 ± 0.42 vs. 1.76 ± 0.17; p = 0.005). Low T2 was associated with shorter survival (Chi-squared 11.3; p < 0.001). Cox regression analysis confirmed T2 ratio < 1.5 as the only independent predictors for survival. CONCLUSION:Cardiac amyloidosis is associated with hypointense signal on T2-weighted images. A lower T2 ratio was independently associated with shortened survival.
Authors: Arnt V Kristen; F Joachim Meyer; Jolanta B Perz; Stefan O Schonland; Michael Hundemer; Ute Hegenbart; Reinhard Singer; Philipp A Schnabel; Falk-Udo Sack; Hartmut Goldschmidt; Hugo A Katus; Thomas J Dengler Journal: Transplantation Date: 2005-09-27 Impact factor: 4.939
Authors: E Perugini; C Rapezzi; T Piva; O Leone; L Bacchi-Reggiani; L Riva; F Salvi; L Lovato; A Branzi; R Fattori Journal: Heart Date: 2005-06-06 Impact factor: 5.994
Authors: Alicia Maria Maceira; Jayshree Joshi; Sanjay Kumar Prasad; James Charles Moon; Enrica Perugini; Idris Harding; Mary Noelle Sheppard; Philip Alexander Poole-Wilson; Philip Nigel Hawkins; Dudley John Pennell Journal: Circulation Date: 2005-01-03 Impact factor: 29.690
Authors: Imran S Syed; James F Glockner; Dali Feng; Philip A Araoz; Matthew W Martinez; William D Edwards; Morie A Gertz; Angela Dispenzieri; Jae K Oh; Diego Bellavia; A Jamil Tajik; Martha Grogan Journal: JACC Cardiovasc Imaging Date: 2010-02
Authors: Peter Hunold; Thomas Schlosser; Florian M Vogt; Holger Eggebrecht; Axel Schmermund; Oliver Bruder; Walter O Schüler; Jörg Barkhausen Journal: AJR Am J Roentgenol Date: 2005-05 Impact factor: 3.959
Authors: Waldemar Hosch; Michael Bock; Martin Libicher; Sebastian Ley; Ute Hegenbart; Thomas J Dengler; Hugo A Katus; Hans-Ulrich Kauczor; Günter W Kauffmann; Arnt V Kristen Journal: Invest Radiol Date: 2007-09 Impact factor: 6.016
Authors: Alicia M Maceira; Sanjay K Prasad; Philip N Hawkins; Michael Roughton; Dudley J Pennell Journal: J Cardiovasc Magn Reson Date: 2008-11-25 Impact factor: 5.364
Authors: Raymond Y Kwong; Bobak Heydari; Siddique Abbasi; Kevin Steel; Mouaz Al-Mallah; Henry Wu; Rodney H Falk Journal: Am J Cardiol Date: 2015-05-22 Impact factor: 2.778
Authors: Wael A Aljaroudi; Milind Y Desai; W H Wilson Tang; Dermot Phelan; Manuel D Cerqueira; Wael A Jaber Journal: J Nucl Cardiol Date: 2014-04 Impact factor: 5.952