Literature DB >> 21720636

Metabolic pathway visualization in living yeast by DNP-NMR.

Sebastian Meier1, Magnus Karlsson, Pernille R Jensen, Mathilde H Lerche, Jens Ø Duus.   

Abstract

Central carbon metabolism of living Saccharomyces cerevisiae is visualized by DNP-NMR. Experiments are conducted as real time assays that detect metabolic bottlenecks, pathway use, reversibility of reactions and reaction mechanisms in vivo with subsecond time resolution.

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Mesh：

Year:  2011        PMID： 21720636     DOI： 10.1039/c1mb05202k

Source DB:  PubMed          Journal:  Mol Biosyst        ISSN： 1742-2051


  24 in total

1.  Efficient Hyperpolarization of U-13 C-Glucose Using Narrow-Line UV-Generated Labile Free Radicals.

Authors:  Andrea Capozzi; Saket Patel; Christine Pepke Gunnarsson; Irene Marco-Rius; Arnaud Comment; Magnus Karlsson; Mathilde H Lerche; Olivier Ouari; Jan Henrik Ardenkjaer-Larsen
Journal:  Angew Chem Int Ed Engl       Date:  2018-12-20       Impact factor: 15.336

Review 2.  Probing carbohydrate metabolism using hyperpolarized 13 C-labeled molecules.

Authors:  Jaspal Singh; Eul Hyun Suh; Gaurav Sharma; Chalermchai Khemtong; A Dean Sherry; Zoltan Kovacs
Journal:  NMR Biomed       Date:  2018-11-26       Impact factor: 4.044

3.  Metabolic Measurements of Nonpermeating Compounds in Live Cells Using Hyperpolarized NMR.

Authors:  Mengxiao Liu; Christian Hilty
Journal:  Anal Chem       Date:  2017-12-27       Impact factor: 6.986

Review 4.  Hyperpolarized (13)C Magnetic Resonance and Its Use in Metabolic Assessment of Cultured Cells and Perfused Organs.

Authors:  Lloyd Lumata; Chendong Yang; Mukundan Ragavan; Nicholas Carpenter; Ralph J DeBerardinis; Matthew E Merritt
Journal:  Methods Enzymol       Date:  2015-06-14       Impact factor: 1.600

5.  Effects of deuteration on transamination and oxidation of hyperpolarized 13C-Pyruvate in the isolated heart.

Authors:  Alexander M Funk; Xiaodong Wen; Thomas Hever; Nesmine R Maptue; Chalermchai Khemtong; A D Sherry; Craig R Malloy
Journal:  J Magn Reson       Date:  2019-03-04       Impact factor: 2.229

6.  Late-stage deuteration of 13C-enriched substrates for T1 prolongation in hyperpolarized 13C MRI.

Authors:  Céline Taglang; David E Korenchan; Cornelius von Morze; Justin Yu; Chloé Najac; Sinan Wang; Joseph E Blecha; Sukumar Subramaniam; Robert Bok; Henry F VanBrocklin; Daniel B Vigneron; Sabrina M Ronen; Renuka Sriram; John Kurhanewicz; David M Wilson; Robert R Flavell
Journal:  Chem Commun (Camb)       Date:  2018-05-17       Impact factor: 6.222

7.  Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized (13)C magnetic resonance spectroscopic imaging.

Authors:  Jae Mo Park; Lawrence D Recht; Sonal Josan; Milton Merchant; Taichang Jang; Yi-Fen Yen; Ralph E Hurd; Daniel M Spielman; Dirk Mayer
Journal:  Neuro Oncol       Date:  2013-01-17       Impact factor: 12.300

Review 8.  Chemistry and biochemistry of 13C hyperpolarized magnetic resonance using dynamic nuclear polarization.

Authors:  Kayvan R Keshari; David M Wilson
Journal:  Chem Soc Rev       Date:  2013-12-20       Impact factor: 54.564

9.  The rate of lactate production from glucose in hearts is not altered by per-deuteration of glucose.

Authors:  Alexander M Funk; Brian L Anderson; Xiaodong Wen; Thomas Hever; Chalermchai Khemtong; Zoltan Kovacs; A Dean Sherry; Craig R Malloy
Journal:  J Magn Reson       Date:  2017-09-18       Impact factor: 2.229

10.  Non-invasive in-cell determination of free cytosolic [NAD+]/[NADH] ratios using hyperpolarized glucose show large variations in metabolic phenotypes.

Authors:  Caspar Elo Christensen; Magnus Karlsson; Jakob R Winther; Pernille Rose Jensen; Mathilde H Lerche
Journal:  J Biol Chem       Date:  2013-12-03       Impact factor: 5.157
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