Literature DB >> 21720424

Overweight as a prognostic factor in children with acute lymphoblastic leukemia.

Cristina B Gelelete1, Sandra H Pereira, Alice Maria B Azevedo, Leandro S Thiago, Mariana Mundim, Marcelo G P Land, Elaine S Costa.   

Abstract

Our purpose was to investigate the prognostic impact of overweight/obesity in 5-year event-free survival (EFS) in a cohort of children with acute lymphoblastic leukemia (ALL). We retrospectively analyzed 181 newly diagnosed ALL children enrolled between 1990 and 2009 and treated with Berlin-Frankfurt-Munich (BFM) protocols. The majority of children in our cohort were <10 years-old. Our data clearly indicated that overweight/obesity is an independent predictor of relapse risk, mainly in the intermediate- and high-risk groups (HR) of children. These results could be explained by changes in the chemotherapy pharmacokinetics in overweight/obese patients and by the antiapoptotic effects in leukemic cells caused by adipocytes.

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Year:  2011        PMID： 21720424     DOI： 10.1038/oby.2011.195

Source DB:  PubMed          Journal:  Obesity (Silver Spring)        ISSN： 1930-7381            Impact factor:   5.002


  21 in total

1.  Impact on survival and toxicity by duration of weight extremes during treatment for pediatric acute lymphoblastic leukemia: A report from the Children's Oncology Group.

Authors:  Etan Orgel; Richard Sposto; Jemily Malvar; Nita L Seibel; Elena Ladas; Paul S Gaynon; David R Freyer
Journal:  J Clin Oncol       Date:  2014-03-31       Impact factor: 44.544

Review 2.  Cell intrinsic and extrinsic regulation of leukemia cell metabolism.

Authors:  Yajian Jiang; Daisuke Nakada
Journal:  Int J Hematol       Date:  2016-02-20       Impact factor: 2.490

Review 3.  B-cell identity as a metabolic barrier against malignant transformation.

Authors:  Lai N Chan; Markus Müschen
Journal:  Exp Hematol       Date:  2017-06-24       Impact factor: 3.084

4.  NK cells in childhood obesity are activated, metabolically stressed, and functionally deficient.

Authors:  Laura M Tobin; Meenal Mavinkurve; Eirin Carolan; David Kinlen; Eoin C O'Brien; Mark A Little; David K Finlay; Declan Cody; Andrew E Hogan; Donal O'Shea
Journal:  JCI Insight       Date:  2017-12-21

5.  PON2 subverts metabolic gatekeeper functions in B cells to promote leukemogenesis.

Authors:  Lili Pan; Chao Hong; Lai N Chan; Gang Xiao; Parmanand Malvi; Mark E Robinson; Huimin Geng; Srinivasa T Reddy; Jaewoong Lee; Vishal Khairnar; Kadriye Nehir Cosgun; Liang Xu; Kohei Kume; Teresa Sadras; Shaoyuan Wang; Narendra Wajapeyee; Markus Müschen
Journal:  Proc Natl Acad Sci U S A       Date:  2021-02-16       Impact factor: 11.205

6.  Adipocytes cause leukemia cell resistance to L-asparaginase via release of glutamine.

Authors:  Ehsan A Ehsanipour; Xia Sheng; James W Behan; Xingchao Wang; Anna Butturini; Vassilios I Avramis; Steven D Mittelman
Journal:  Cancer Res       Date:  2013-04-12       Impact factor: 12.701

7.  Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche.

Authors:  Haobin Ye; Biniam Adane; Nabilah Khan; Timothy Sullivan; Mohammad Minhajuddin; Maura Gasparetto; Brett Stevens; Shanshan Pei; Marlene Balys; John M Ashton; Dwight J Klemm; Carolien M Woolthuis; Alec W Stranahan; Christopher Y Park; Craig T Jordan
Journal:  Cell Stem Cell       Date:  2016-06-30       Impact factor: 24.633

8.  The negative impact of being underweight and weight loss on survival of children with acute lymphoblastic leukemia.

Authors:  Marissa A H den Hoed; Saskia M F Pluijm; Hester A de Groot-Kruseman; Mariël L te Winkel; Martha Fiocco; Erica L T van den Akker; Peter Hoogerbrugge; Henk van den Berg; Jan A Leeuw; Marrie C A Bruin; Dorine Bresters; Anjo J P Veerman; Rob Pieters; Marry M van den Heuvel-Eibrink
Journal:  Haematologica       Date:  2014-10-10       Impact factor: 9.941

Review 9.  The role of adipose tissue and obesity in causing treatment resistance of acute lymphoblastic leukemia.

Authors:  Xia Sheng; Steven D Mittelman
Journal:  Front Pediatr       Date:  2014-06-05       Impact factor: 3.418

10.  Restoration of H3k27me3 Modification Epigenetically Silences Cry1 Expression and Sensitizes Leptin Signaling to Reduce Obesity-Related Properties.

Authors:  Yan Wei; Jun Chen; Xing Xu; Fan Li; Kun Wu; Yingying Jiang; Yuqing Rao; Chen Zhao; Wantao Chen; Xu Wang
Journal:  Adv Sci (Weinh)       Date:  2021-05-13       Impact factor: 16.806
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