Literature DB >> 21720305

WNT/β-catenin signaling in polycystic kidney disease.

Anne Wuebken1, Kai M Schmidt-Ott.   

Abstract

Cystic kidney diseases have been linked to defective WNT signal transduction. Perturbations of cystic disease genes cause activation of canonical WNT/β-catenin/TCF/Lef1 signaling in model organisms and cultured cells. Inappropriate levels of WNT/β-catenin signaling cause renal cyst formation in mice. These observations have prompted the idea that an activation of WNT/β-catenin signaling may constitute a common causative event in cyst formation. Now this view is challenged by key genetic mouse models of cystic kidney disease that do not display WNT/β-catenin activity in cyst-lining epithelia.

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Year:  2011        PMID： 21720305     DOI： 10.1038/ki.2011.87

Source DB:  PubMed          Journal:  Kidney Int        ISSN： 0085-2538            Impact factor:   10.612


  19 in total

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