Literature DB >> 2172028

The biological activity of retinoids in melanoma cells. Induction of expression of retinoic acid receptor-beta by retinoic acid in S91 melanoma cells.

C P Redfern1, A K Daly, J A Latham, C Todd.   

Abstract

The expression of mRNA for retinoic acid receptor beta (RAR-beta) was induced by all trans-retinoic acid in murine S91 melanoma cells. The induction of RAR-beta was dose-dependent, rapid and insensitive to cycloheximide. Both 13-cis-retinoic acid and 3,4-didehydro-all trans-retinoic acid also induced expression of RAR-beta but were only effective at concentrations 100-fold greater than all trans-retinoic acid. The expression of RAR-alpha and RAR-gamma was unaffected by retinoic acid.

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Year:  1990        PMID： 2172028     DOI： 10.1016/0014-5793(90)81041-l

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  5 in total

1.  Differentiation of pancreatic carcinoma induced by retinoic acid or sodium butyrate: a morphological and molecular analysis of four cell lines.

Authors:  N Egawa; B Maillet; B VanDamme; J De Grève; G Klöppel
Journal:  Virchows Arch       Date:  1996-09       Impact factor: 4.064

2.  Differential effects of 9-cis and all-trans retinoic acid on the induction of retinoic acid receptor-beta and cellular retinoic acid-binding protein II in human neuroblastoma cells.

Authors:  C P Redfern; P E Lovat; A J Malcolm; A D Pearson
Journal:  Biochem J       Date:  1994-11-15       Impact factor: 3.857

3.  Retinoic acid affects the expression of nuclear retinoic acid receptors in tissues of retinol-deficient rats.

Authors:  R Haq; M Pfahl; F Chytil
Journal:  Proc Natl Acad Sci U S A       Date:  1991-09-15       Impact factor: 11.205

4.  Combination of highly purified human leukocyte interferon alpha and 13-cis-retinoic acid for the treatment of metastatic melanoma.

Authors:  G Fierlbeck; T Schreiner; G Rassner
Journal:  Cancer Immunol Immunother       Date:  1995-03       Impact factor: 6.968

5.  All-trans-retinoic acid metabolites significantly inhibit the proliferation of MCF-7 human breast cancer cells in vitro.

Authors:  J Van heusden; W Wouters; F C Ramaekers; M D Krekels; L Dillen; M Borgers; G Smets
Journal:  Br J Cancer       Date:  1998       Impact factor: 7.640
  5 in total

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