Literature DB >> 2171996

Evidence for communication between nerve growth factor and protein tyrosine phosphorylation.

N Gómez1, N K Tonks, C Morrison, T Harmar, P Cohen.   

Abstract

Nerve growth factor (NGF) stimulation of PC12 cells activated two myelin basic protein (MBP) kinase activities greater than 10-fold within 5 min, which were resolved by chromatography on Mono Q. Each enzyme phosphorylated MBP on threonine and was inactivated by incubation with either CD45, a protein tyrosine phosphatase, or protein phosphatase 2A (PP2A), a serine/threonine phosphatase. The effects of CD45 and PP2A were prevented by vanadate and okadaic acid, respectively. Activation of the MBP-kinases provides a mechanism for communication between NGF and intracellular protein tyrosine phosphorylation.

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Year:  1990        PMID： 2171996     DOI： 10.1016/0014-5793(90)80386-w

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  35 in total

1.  Inhibition of c-Jun DNA binding by mitogen-activated protein kinase.

Authors:  S Y Chou; V Baichwal; J E Ferrell
Journal:  Mol Biol Cell       Date:  1992-10       Impact factor: 4.138

Review 2.  Nuclear protein phosphorylation and growth control.

Authors:  D W Meek; A J Street
Journal:  Biochem J       Date:  1992-10-01       Impact factor: 3.857

3.  The beta-PDGF receptor induces neuronal differentiation of PC12 cells.

Authors:  L E Heasley; G L Johnson
Journal:  Mol Biol Cell       Date:  1992-05       Impact factor: 4.138

Review 4.  Extracellular signal-regulated kinases: ERKs in progress.

Authors:  M H Cobb; T G Boulton; D J Robbins
Journal:  Cell Regul       Date:  1991-12

5.  Nerve growth factor stimulates protein tyrosine phosphorylation in PC-12 pheochromocytoma cells.

Authors:  T Miyasaka; D W Sternberg; J Miyasaka; P Sherline; A R Saltiel
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-01       Impact factor: 11.205

6.  A role for the SHP-2 tyrosine phosphatase in nerve growth-induced PC12 cell differentiation.

Authors:  J H Wright; P Drueckes; J Bartoe; Z Zhao; S H Shen; E G Krebs
Journal:  Mol Biol Cell       Date:  1997-08       Impact factor: 4.138

7.  Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor.

Authors:  S Traverse; N Gomez; H Paterson; C Marshall; P Cohen
Journal:  Biochem J       Date:  1992-12-01       Impact factor: 3.857

8.  A role for autophosphorylation revealed by activated alleles of FUS3, the yeast MAP kinase homolog.

Authors:  J A Brill; E A Elion; G R Fink
Journal:  Mol Biol Cell       Date:  1994-03       Impact factor: 4.138

9.  Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product.

Authors:  C M Crews; R L Erikson
Journal:  Proc Natl Acad Sci U S A       Date:  1992-09-01       Impact factor: 11.205

10.  Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies.

Authors:  T G Boulton; M H Cobb
Journal:  Cell Regul       Date:  1991-05
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