George R Uhl1, Donna Walther, Frederique M Behm, Jed E Rose. 1. Molecular Neurobiology, National Institutes of Health-Intramural Research Program, National Institute on Drug Abuse, Box 5180, Baltimore, MD 21224, USA. guhl@intra.nida.nih.gov
Abstract
INTRODUCTION: Preference for smoking menthol cigarettes differs from individual to individual and population to population in ways that may provide higher levels of nicotine intake and contribute to smoking's morbidity and mortality. Menthol acts at sites that include the transient receptor potential (TRP) A1 channel that is expressed by nociceptors in the lung and airways, suggesting that individual and population differences in TRPA1 sequences might contribute to observed differences in menthol preference among smokers. METHODS: We have thus sought association between menthol preference and common variants in the TRPA1 gene in heavier and lighter European-American smokers. Smokers were recruited for studies of smoking cessation in North Carolina and of substance abuse genetics in Maryland. RESULTS: A common TRPA1 haplotype is defined by 1 missense and 10 intronic single nucleotide polymorphisms that display significant (.006 < p < .05; χ(2)) association with preference for mentholated cigarettes in heavy smokers (odds ratio ca. 1.3). There are smaller trends in the same direction in lighter smokers. CONCLUSIONS: This TRPA1 haplotype provides a novel biological basis for individual differences in menthol preference and possibly for actions of other agents that act at TRPA1.
INTRODUCTION: Preference for smoking menthol cigarettes differs from individual to individual and population to population in ways that may provide higher levels of nicotine intake and contribute to smoking's morbidity and mortality. Menthol acts at sites that include the transient receptor potential (TRP) A1 channel that is expressed by nociceptors in the lung and airways, suggesting that individual and population differences in TRPA1 sequences might contribute to observed differences in menthol preference among smokers. METHODS: We have thus sought association between menthol preference and common variants in the TRPA1 gene in heavier and lighter European-American smokers. Smokers were recruited for studies of smoking cessation in North Carolina and of substance abuse genetics in Maryland. RESULTS: A common TRPA1 haplotype is defined by 1 missense and 10 intronic single nucleotide polymorphisms that display significant (.006 < p < .05; χ(2)) association with preference for mentholated cigarettes in heavy smokers (odds ratio ca. 1.3). There are smaller trends in the same direction in lighter smokers. CONCLUSIONS: This TRPA1 haplotype provides a novel biological basis for individual differences in menthol preference and possibly for actions of other agents that act at TRPA1.
Authors: Y Osaki; T Tanihata; T Ohida; M Minowa; K Wada; K Suzuki; A Kaetsu; M Okamoto; T Kishimoto Journal: Tob Control Date: 2006-06 Impact factor: 7.552
Authors: Yuji Karashima; Nils Damann; Jean Prenen; Karel Talavera; Andrei Segal; Thomas Voets; Bernd Nilius Journal: J Neurosci Date: 2007-09-12 Impact factor: 6.167
Authors: Luciano De Petrocellis; Alessia Ligresti; Aniello Schiano Moriello; Marco Allarà; Tiziana Bisogno; Stefania Petrosino; Colin G Stott; Vincenzo Di Marzo Journal: Br J Pharmacol Date: 2011-08 Impact factor: 8.739
Authors: Kari Jo Harris; Kolawole S Okuyemi; Delwyn Catley; Matthew S Mayo; Bin Ge; Jasjit S Ahluwalia Journal: Prev Med Date: 2004-04 Impact factor: 4.018
Authors: Gerald W Valentine; Elise E DeVito; Peter I Jatlow; Ralitza Gueorguieva; Mehmet Sofuoglu Journal: J Psychopharmacol Date: 2018-05-23 Impact factor: 4.153
Authors: Valentina Gallo; F Nicole Dijk; John W Holloway; Susan M Ring; Gerard H Koppelman; Dirkje S Postma; David P Strachan; Raquel Granell; Johan C de Jongste; Vincent W V Jaddoe; Herman T den Dekker; Liesbeth Duijts; A John Henderson; Seif O Shaheen Journal: Pediatr Allergy Immunol Date: 2016-12-08 Impact factor: 6.377