BACKGROUND AND PURPOSE: The purpose of this study was to assess the association of vitamin D deficiency and indices of mineral metabolism with subclinical carotid markers that predict cardiovascular events. METHODS: Two hundred three community-dwelling adults (Northern Manhattan Study; age, 68 ± 11; age range, 50 to 93 years) had serum measurements (calcium, phosphorus, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, parathyroid hormone) and carotid ultrasound (plaque presence, number, maximal carotid plaque thickness, intima-media thickness). RESULTS: Adjusting for cardiovascular risk factors, plaque number was associated with phosphorus levels (β=0.39 per 1-mg/dL increase; P=0.02) and calcium-phosphorus product (β=0.36 per 10-U increase; P=0.03). In those with plaque (N=116 [57%]), the association of plaque number with phosphorus and calcium-phosphorus product persisted. In addition, 25-hydroxyvitamin D was inversely associated with both intima-media thickness (β=-0.01 per 10-ng/mL increase; P=0.05) and maximal carotid plaque thickness (β=-0.10 per 10-ng/mL increase; P=0.03). In a model containing traditional cardiac risk factors and indices of mineral metabolism, 25-hydroxyvitamin D accounted for 13% of the variance in both intima-media thickness and maximal carotid plaque thickness. Calcium, parathyroid hormone, and 1,25-dihydroxyvitamin D levels were not associated with carotid measures. CONCLUSIONS: After adjusting for cardiovascular risk factors and renal function, serum phosphorus and calcium-phosphorus product were associated with a greater burden of subclinical carotid atherosclerosis. Low 25-hydroxyvitamin D levels were associated with increased intima-media thickness and maximal carotid plaque thickness in those with plaque, and 25-hydroxyvitamin D contributed in a robust manner to the variance in both. These results confirm and extend data on the association of low vitamin D levels with subclinical carotid atherosclerosis. The precise nature of this association and the optimum levels of vitamin D for vascular health remain to be elucidated.
BACKGROUND AND PURPOSE: The purpose of this study was to assess the association of vitamin Ddeficiency and indices of mineral metabolism with subclinical carotid markers that predict cardiovascular events. METHODS: Two hundred three community-dwelling adults (Northern Manhattan Study; age, 68 ± 11; age range, 50 to 93 years) had serum measurements (calcium, phosphorus, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, parathyroid hormone) and carotid ultrasound (plaque presence, number, maximal carotid plaque thickness, intima-media thickness). RESULTS: Adjusting for cardiovascular risk factors, plaque number was associated with phosphorus levels (β=0.39 per 1-mg/dL increase; P=0.02) and calcium-phosphorus product (β=0.36 per 10-U increase; P=0.03). In those with plaque (N=116 [57%]), the association of plaque number with phosphorus and calcium-phosphorus product persisted. In addition, 25-hydroxyvitamin D was inversely associated with both intima-media thickness (β=-0.01 per 10-ng/mL increase; P=0.05) and maximal carotid plaque thickness (β=-0.10 per 10-ng/mL increase; P=0.03). In a model containing traditional cardiac risk factors and indices of mineral metabolism, 25-hydroxyvitamin D accounted for 13% of the variance in both intima-media thickness and maximal carotid plaque thickness. Calcium, parathyroid hormone, and 1,25-dihydroxyvitamin D levels were not associated with carotid measures. CONCLUSIONS: After adjusting for cardiovascular risk factors and renal function, serum phosphorus and calcium-phosphorus product were associated with a greater burden of subclinical carotid atherosclerosis. Low 25-hydroxyvitamin D levels were associated with increased intima-media thickness and maximal carotid plaque thickness in those with plaque, and 25-hydroxyvitamin D contributed in a robust manner to the variance in both. These results confirm and extend data on the association of low vitamin D levels with subclinical carotid atherosclerosis. The precise nature of this association and the optimum levels of vitamin D for vascular health remain to be elucidated.
Authors: Jun Sun; Juan Kong; Yingli Duan; Frances L Szeto; Anne Liao; James L Madara; Yan Chun Li Journal: Am J Physiol Endocrinol Metab Date: 2006-02-28 Impact factor: 4.310
Authors: Jun Oh; Rainer Wunsch; Martin Turzer; Malte Bahner; Paolo Raggi; Uwe Querfeld; Otto Mehls; Franz Schaefer Journal: Circulation Date: 2002-07-02 Impact factor: 29.690
Authors: Tatjana Rundek; Rameet Hundle; Elizabeth Ratchford; Romel Ramas; Robert Sciacca; Marco R Di Tullio; Bernadette Boden-Albala; Yumiko Miyake; Mitchell S V Elkind; Ralph L Sacco; Shunichi Homma Journal: BMC Cardiovasc Disord Date: 2006-08-17 Impact factor: 2.298
Authors: Marcella D Walker; Elaine Cong; Anna Kepley; Marco R Di Tullio; Tatjana Rundek; Shunichi Homma; James A Lee; Rui Liu; Polly Young; Chiyuan Zhang; Donald J McMahon; Shonni J Silverberg Journal: J Clin Endocrinol Metab Date: 2013-11-27 Impact factor: 5.958
Authors: Sara Alsulaimani; Hannah Gardener; Mitchell S V Elkind; Ken Cheung; Ralph L Sacco; Tatjana Rundek Journal: Stroke Date: 2013-01-03 Impact factor: 7.914
Authors: Gotaro Kojima; Christina L Bell; Randi Chen; G Webster Ross; Robert D Abbott; Lenore Launer; Felix Lui; Kamal Masaki Journal: J Am Coll Nutr Date: 2014 Impact factor: 3.169
Authors: J S McNally; T M Burton; B W Aldred; S-E Kim; M S McLaughlin; L B Eisenmenger; G J Stoddard; J J Majersik; D V Miller; G S Treiman; D L Parker Journal: AJNR Am J Neuroradiol Date: 2016-06-16 Impact factor: 3.825
Authors: Rona J Strawbridge; Anna Deleskog; Olga McLeod; Lasse Folkersen; Maryam Kavousi; Karl Gertow; Damiano Baldassarre; Fabrizio Veglia; Karin Leander; Bruna Gigante; Jussi Kauhanen; Rainer Rauramaa; Andries J Smit; Elmo Mannarino; Philippe Giral; Abbas Dehghan; Albert Hofman; Oscar H Franco; Steve E Humphries; Elena Tremoli; Ulf de Faire; Sven Gustafsson; Claes-Göran Östensson; Per Eriksson; John Öhrvik; Anders Hamsten Journal: Diabetologia Date: 2014-03-25 Impact factor: 10.122