OBJECTIVES: To evaluate long-term clinical outcomes of overlapping heterogeneous drug-eluting stents (DES) compared with homogeneous DES. DESIGN AND SETTING: The catholic medical centre coronary intervention database is a multicentre database of percutaneous coronary intervention with DES. This database contains data on consecutive patients from eight coronary intervention centres in Korea. PATIENTS: Overlapping homogeneous DES were used in 940 patients and overlapping heterogeneous DES in 140 patients between January 2005 and June 2010. INTERVENTION: The study enrolled patients with one-vessel disease treated with two overlapping DES in one lesion. MAIN OUTCOME MEASURES: The study end point was the occurrence of major adverse cardiac events (MACE), defined as cardiac death, myocardial infarction (MI) or target lesion revascularisation (TRL). RESULTS: The two patient groups had similar baseline clinical and angiographic characteristics. MACE, cardiac death, MI and TRL rates, were not significantly different between the homogeneous and heterogeneous DES groups (9.9% vs 11.4%, p=0.574; 2.7% vs 3.6%, p=0.578; 1.5% vs 1.4%, p=1.000; 5.7% vs 6.4%, p=0.747, respectively). In addition, it was found that overlap with second-generation DES may be safe and effective, and the sirolimus-eluting stent (SES)+SES group had higher rate of MACE-free survival than the paclitaxel-eluting stent (PES)+PES group (p=0.014). CONCLUSIONS: Overlapping heterogeneous DES and overlapping homogeneous DES had similar long-term safety and efficacy outcomes.
OBJECTIVES: To evaluate long-term clinical outcomes of overlapping heterogeneous drug-eluting stents (DES) compared with homogeneous DES. DESIGN AND SETTING: The catholic medical centre coronary intervention database is a multicentre database of percutaneous coronary intervention with DES. This database contains data on consecutive patients from eight coronary intervention centres in Korea. PATIENTS: Overlapping homogeneous DES were used in 940 patients and overlapping heterogeneous DES in 140 patients between January 2005 and June 2010. INTERVENTION: The study enrolled patients with one-vessel disease treated with two overlapping DES in one lesion. MAIN OUTCOME MEASURES: The study end point was the occurrence of major adverse cardiac events (MACE), defined as cardiac death, myocardial infarction (MI) or target lesion revascularisation (TRL). RESULTS: The two patient groups had similar baseline clinical and angiographic characteristics. MACE, cardiac death, MI and TRL rates, were not significantly different between the homogeneous and heterogeneous DES groups (9.9% vs 11.4%, p=0.574; 2.7% vs 3.6%, p=0.578; 1.5% vs 1.4%, p=1.000; 5.7% vs 6.4%, p=0.747, respectively). In addition, it was found that overlap with second-generation DES may be safe and effective, and the sirolimus-eluting stent (SES)+SES group had higher rate of MACE-free survival than the paclitaxel-eluting stent (PES)+PES group (p=0.014). CONCLUSIONS: Overlapping heterogeneous DES and overlapping homogeneous DES had similar long-term safety and efficacy outcomes.
Authors: Seung-Woon Rha; Kang-Yin Chen; Dong Joo Oh; Yong-Jian Li; Zhe Jin; Kanhaiya Lal Poddar; Sureshkumar Ramasamy; Yoshiyasu Minami; Amro Elnagar; Byoung Geol Choi; Sang Pyo Hong; Byoung Won Cheon; Sang Ki Moon; Sung Il Im; Sun Won Kim; Jin Oh Na; Cheol Ung Choi; Hong Euy Lim; Jin Won Kim; Eung Ju Kim; Seong Woo Han; Chang Gyu Park; Hong Seog Seo; Jung Ha Kim; Young Joon Hong; Myung Ho Jeong Journal: Korean Circ J Date: 2012-06-28 Impact factor: 3.243