| Literature DB >> 21719282 |
Suzanne S Stokes1, Hoan Huynh, Madhusudhan Gowravaram, Robert Albert, Marta Cavero-Tomas, Brendan Chen, Jenna Harang, James T Loch, Min Lu, George B Mullen, Shannon Zhao, Ce-Feng Liu, Scott D Mills.
Abstract
Optimization of adenosine analog inhibitors of bacterial NAD(+)-dependent DNA ligase is discussed. Antibacterial activity against Streptococcus pneumoniae and Staphylococcus aureus was improved by modification of the 2-position substituent on the adenine ring and 3'- and 5'-substituents on the ribose. Compounds with logD values 1.5-2.5 maximized potency and maintained drug-like physical properties.Entities:
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Year: 2011 PMID： 21719282 DOI： 10.1016/j.bmcl.2011.05.128
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823