| Literature DB >> 21716034 |
Takamura Nagasaka1, Kaori Nagasaka, Emiko Ohta, Kazumasa Shindo, Yoshihisa Takiyama, Zenji Shiozawa, Nobuyuki Miyazawa, Naomi Yamasaki, Nobuhiko Mori, Hideaki Onda, Toyoaki Shinohara.
Abstract
Right cerebral and contralateral cerebellar hypermetabolism were observed on FDG PET in a 68-year-old woman with familial Creutzfeldt-Jakob disease (CJD) at an early stage before seizures occurred. The disease progressed with frequent seizures, myoclonus, and a startle reaction. In all past reports, FDG PET studies demonstrated hypometabolism in the cerebrum, cerebellum, and thalamus in patients with CJD. Focal hypermetabolism corresponding with epileptic foci is a common finding in ictal epilepsy patients, and hypometabolism is common in patients with myoclonus or the startle reaction. This finding may reflect a prodromal pathophysiology of epilepsy. Attention should be paid to the diagnosis of CJD while using FDG PET.Entities:
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Year: 2011 PMID： 21716034 DOI： 10.1097/RLU.0b013e31821a2604
Source DB: PubMed Journal: Clin Nucl Med ISSN： 0363-9762 Impact factor: 7.794