PURPOSE: Kikuchi-Fujimoto disease (KFD), formerly called subacute necrotizing lymphadenitis, is a rare cause of cervical lymphadenopathy. The purpose of this study was to evaluate the usefulness of FDG PET/CT for distinguishing KFD from non-Hodgkin lymphoma (NHL). MATERIALS AND METHODS: Twenty-two patients with cervical lymphadenopathy (8 with KFD and 14 with NHL) underwent CT and FDG PET/CT scans to examine the cervical lymphadenopathy. Regional values of FDG uptake were evaluated using the standardized uptake value (SUV) and partial volume corrected SUV (corSUV) based on the count recovery coefficient. Tumor size (mm), SUV, and corSUV were compared among KFD, indolent NHL, and aggressive NHL. RESULTS: KFD lesions tended to be smaller (13.8 ± 5.4 mm) than those of indolent (25.4 ± 11.8) and aggressive (29.7 ± 18.8) NHL, whereas there were no significant differences in size. As for SUV, a significant difference was observed only between indolent and aggressive (6.4 ± 1.5 and 17.3 ± 9.3, P < 0.05) NHL; however, KFD showed a significantly greater corSUV (23.8 ± 10.6) as compared with indolent NHL (9.2 ± 5.1, P < 0.05), which did not show a significant difference from aggressive NHL (21.4 ± 10.2). FDG PET/CT detected thoracoabdominal lesions in 2 patients (25%) with KFD. CONCLUSIONS: KFD shows high FDG uptake for size, which may reflect the pathologic characteristics, including necrotizing lymphocytes and numerous histiocytes (macrophages) surrounding small necrotic foci. FDG PET/CT will be useful for detecting noncervical lesions of KFD and distinguishing KFD from NHLs using both SUV and corSUV.
PURPOSE:Kikuchi-Fujimoto disease (KFD), formerly called subacute necrotizing lymphadenitis, is a rare cause of cervical lymphadenopathy. The purpose of this study was to evaluate the usefulness of FDG PET/CT for distinguishing KFD from non-Hodgkin lymphoma (NHL). MATERIALS AND METHODS: Twenty-two patients with cervical lymphadenopathy (8 with KFD and 14 with NHL) underwent CT and FDG PET/CT scans to examine the cervical lymphadenopathy. Regional values of FDG uptake were evaluated using the standardized uptake value (SUV) and partial volume corrected SUV (corSUV) based on the count recovery coefficient. Tumor size (mm), SUV, and corSUV were compared among KFD, indolent NHL, and aggressive NHL. RESULTS:KFD lesions tended to be smaller (13.8 ± 5.4 mm) than those of indolent (25.4 ± 11.8) and aggressive (29.7 ± 18.8) NHL, whereas there were no significant differences in size. As for SUV, a significant difference was observed only between indolent and aggressive (6.4 ± 1.5 and 17.3 ± 9.3, P < 0.05) NHL; however, KFD showed a significantly greater corSUV (23.8 ± 10.6) as compared with indolent NHL (9.2 ± 5.1, P < 0.05), which did not show a significant difference from aggressive NHL (21.4 ± 10.2). FDG PET/CT detected thoracoabdominal lesions in 2 patients (25%) with KFD. CONCLUSIONS: KFD shows high FDG uptake for size, which may reflect the pathologic characteristics, including necrotizing lymphocytes and numerous histiocytes (macrophages) surrounding small necrotic foci. FDG PET/CT will be useful for detecting noncervical lesions of KFD and distinguishing KFD from NHLs using both SUV and corSUV.
Authors: Ji Eun Kim; Eun Kyung Lee; Jae Min Lee; Soon Hwan Bae; Kwang Hae Choi; Young Hwan Lee; Jeong Ok Hah; Joon Hyuk Choi; Eun Jung Kong; Ihn Ho Cho Journal: Korean J Pediatr Date: 2014-05-31
Authors: Jun Zhang; Meng-Jie Dong; Kan-Feng Liu; Li-Ming Xu; Kui Zhao; Jun Yang; Wan-Wen Weng; Hong Qiu; Li-Li Lin; Yang-Jun Zhu Journal: Int J Clin Exp Med Date: 2015-11-15
Authors: Matthijs C F Cysouw; Gerbrand M Kramer; Linda J Schoonmade; Ronald Boellaard; Henrica C W de Vet; Otto S Hoekstra Journal: Eur J Nucl Med Mol Imaging Date: 2017-08-04 Impact factor: 9.236
Authors: Jane Date Hon; Maria E Vergara-Lluri; Imran Siddiqi; Christopher Foss; Donald I Feinstein; Russell K Brynes Journal: Hematol Rep Date: 2021-03-05