PURPOSE: To determine the association between the ocular perfusion pressure (OPP; essentially the difference between the blood pressure and the intraocular pressure [IOP]) and incident open-angle glaucoma (OAG). METHODS: A subset of 3882 participants of the population-based Rotterdam Study for whom data from ophthalmic examinations at baseline and follow-up and blood pressure measurements at baseline were available, and who did not have OAG at baseline, were included. Associations between the mean, systolic and diastolic OPP, and incident OAG were assessed using Cox regression models adjusted for age and sex, with and without adjustment for IOP. RESULTS: During a mean follow-up of 9.8 years, 103 participants (2.7%) developed OAG. The association between the mean OPP and incident OAG was not significant (hazard ratio 0.995 per mm Hg increase in mean OPP; 95% confidence interval 0.971-1.019) when adjusted for IOP, but became significant if not adjusted for IOP (0.968; 0.945-0.992). The systolic and diastolic OPP showed a pattern similar to that of the mean OPP, though less significant. CONCLUSIONS: The OPP appears to be associated with incident OAG but this association seems to be due to the fact that the IOP, a strong risk factor for OAG, is part of the OPP, rather than that OPP is an independent OAG risk factor itself.
PURPOSE: To determine the association between the ocular perfusion pressure (OPP; essentially the difference between the blood pressure and the intraocular pressure [IOP]) and incident open-angle glaucoma (OAG). METHODS: A subset of 3882 participants of the population-based Rotterdam Study for whom data from ophthalmic examinations at baseline and follow-up and blood pressure measurements at baseline were available, and who did not have OAG at baseline, were included. Associations between the mean, systolic and diastolic OPP, and incident OAG were assessed using Cox regression models adjusted for age and sex, with and without adjustment for IOP. RESULTS: During a mean follow-up of 9.8 years, 103 participants (2.7%) developed OAG. The association between the mean OPP and incident OAG was not significant (hazard ratio 0.995 per mm Hg increase in mean OPP; 95% confidence interval 0.971-1.019) when adjusted for IOP, but became significant if not adjusted for IOP (0.968; 0.945-0.992). The systolic and diastolic OPP showed a pattern similar to that of the mean OPP, though less significant. CONCLUSIONS: The OPP appears to be associated with incident OAG but this association seems to be due to the fact that the IOP, a strong risk factor for OAG, is part of the OPP, rather than that OPP is an independent OAG risk factor itself.
Authors: Mary E Charlson; Carlos Gustavo de Moraes; Alissa Link; Martin T Wells; Gregory Harmon; Janey C Peterson; Robert Ritch; Jeffrey M Liebmann Journal: Ophthalmology Date: 2014-05-25 Impact factor: 12.079
Authors: Alon Harris; Giovanna Guidoboni; Brent Siesky; Sunu Mathew; Alice C Verticchio Vercellin; Lucas Rowe; Julia Arciero Journal: Prog Retin Eye Res Date: 2020-01-24 Impact factor: 21.198
Authors: Alessandro A Jammal; Samuel I Berchuck; Eduardo B Mariottoni; Angelo P Tanna; Vital P Costa; Felipe A Medeiros Journal: Ophthalmology Date: 2021-08-30 Impact factor: 12.079
Authors: Hugues Aschard; Jae H Kang; Adriana I Iglesias; Pirro Hysi; Jessica N Cooke Bailey; Anthony P Khawaja; R Rand Allingham; Allison Ashley-Koch; Richard K Lee; Sayoko E Moroi; Murray H Brilliant; Gadi Wollstein; Joel S Schuman; John H Fingert; Donald L Budenz; Tony Realini; Terry Gaasterland; William K Scott; Kuldev Singh; Arthur J Sit; Robert P Igo; Yeunjoo E Song; Lisa Hark; Robert Ritch; Douglas J Rhee; Vikas Gulati; Shane Haven; Douglas Vollrath; Donald J Zack; Felipe Medeiros; Robert N Weinreb; Ching-Yu Cheng; Daniel I Chasman; William G Christen; Margaret A Pericak-Vance; Yutao Liu; Peter Kraft; Julia E Richards; Bernard A Rosner; Michael A Hauser; Caroline C W Klaver; Cornelia M vanDuijn; Jonathan Haines; Janey L Wiggs; Louis R Pasquale Journal: Eur J Hum Genet Date: 2017-08-30 Impact factor: 5.351