Literature DB >> 2171512

Endothelin/sarafotoxin receptor induced phosphoinositide turnover: effects of pertussis and cholera toxins and of phorbol ester.

R Galron1, A Bdolah, Y Kloog, M Sokolovsky.   

Abstract

The induction of phosphoinositide hydrolysis (PI) by endothelin/sarafotoxin (ET/SRTX) receptors in rat heart myocytes was investigated by the use of bacterial toxins as well as a phorbol ester. Both pertussis- and choleratoxin enhanced the stimulation of PI hydrolysis. Phorbol ester treatment of the myocytes for short periods distinguished between two types of PI-hydrolysis, the one induced by endothelins and the other by sarafotoxins. The possible mediation of G-protein (s) in the induction by ET/SRTX receptors of PI-hydrolysis is discussed.

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Year:  1990        PMID： 2171512     DOI： 10.1016/0006-291x(90)90776-j

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

1.  Role of Na+/Ca2+ exchange in endothelin-1-induced increases in Ca2+ transient and contractility in rabbit ventricular myocytes: pharmacological analysis with KB-R7943.

Authors:  H T Yang; K Sakurai; H Sugawara; T Watanabe; I Norota; M Endoh
Journal:  Br J Pharmacol       Date:  1999-04       Impact factor: 8.739

2.  Pharmacological analysis by HOE642 and KB-R9032 of the role of Na(+)/H(+) exchange in the endothelin-1-induced Ca(2+) signalling in rabbit ventricular myocytes.

Authors:  H Wang; K Sakurai; M Endoh
Journal:  Br J Pharmacol       Date:  2000-10       Impact factor: 8.739

3.  Bradykinin-stimulated phosphoinositide metabolism in cultured canine tracheal smooth muscle cells.

Authors:  C M Yang; H C Hsia; S P Chou; R Ong; J T Hsieh; S F Luo
Journal:  Br J Pharmacol       Date:  1994-01       Impact factor: 8.739

4.  5-Hydroxytryptamine receptor-mediated phosphoinositide hydrolysis in canine cultured tracheal smooth muscle cells.

Authors:  C M Yang; Y L Yo; J T Hsieh; R Ong
Journal:  Br J Pharmacol       Date:  1994-03       Impact factor: 8.739

5.  Role of extracellular and intracellular sources of Ca2+ in sarafotoxin S6b-induced contraction of strips of the rat aorta.

Authors:  C Watanabe; K Hirano; H Kanaide
Journal:  Br J Pharmacol       Date:  1993-01       Impact factor: 8.739

6.  Failure of BQ123, a more potent antagonist of sarafotoxin 6b than of endothelin-1, to distinguish between these agonists in binding experiments.

Authors:  J J Maguire; R E Kuc; B A Rous; A P Davenport
Journal:  Br J Pharmacol       Date:  1996-05       Impact factor: 8.739
  6 in total

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