Literature DB >> 2171508

A synthetic peptide corresponding to residues 137 to 157 of p60v-src inhibits tyrosine-specific protein kinases.

K Sato1, S Miki, H Tachibana, F Hayashi, T Akiyama, Y Fukami.   

Abstract

A 21-residue synthetic peptide corresponding to a part of the noncatalytic domain of p60v-src (residues 137 to 157) was found to inhibit the tyrosine kinase activity of p60v-src. The half inhibition concentration was ca. 7.5 microM. The peptide (peptide A) did not compete with substrate proteins or ATP. Peptide A also inhibited the autophosphorylation of epidermal growth factor receptor/kinase and the tyrosine-specific protein phosphorylation in the acetylcholine receptor-rich membranes isolated from electroplax of Narke japonica. However, serine/threonine-specific protein kinases such as cAMP-dependent and cGMP-dependent protein kinases were not inhibited by peptide A.

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Year:  1990        PMID： 2171508     DOI： 10.1016/0006-291x(90)90805-w

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

1.  Mechanical stretch induces vascular permeability factor in human mesangial cells: mechanisms of signal transduction.

Authors:  G Gruden; S Thomas; D Burt; S Lane; G Chusney; S Sacks; G Viberti
Journal:  Proc Natl Acad Sci U S A       Date:  1997-10-28       Impact factor: 11.205

2.  Environmental neurotoxic pesticide dieldrin activates a non receptor tyrosine kinase to promote PKCδ-mediated dopaminergic apoptosis in a dopaminergic neuronal cell model.

Authors:  Hariharan Saminathan; Arunkumar Asaithambi; Vellareddy Anantharam; Anumantha G Kanthasamy; Arthi Kanthasamy
Journal:  Neurotoxicology       Date:  2011-07-23       Impact factor: 4.294

3.  Novel form of crosstalk between G protein and tyrosine kinase pathways.

Authors:  M Diversé-Pierluissi; A E Remmers; R R Neubig; K Dunlap
Journal:  Proc Natl Acad Sci U S A       Date:  1997-05-13       Impact factor: 11.205

4.  Effects of protein tyrosine kinase inhibitors on voltage-operated calcium channel currents in vascular smooth muscle cells and pp60(c-src) kinase activity.

Authors:  S Wijetunge; J S Lymn; A D Hughes
Journal:  Br J Pharmacol       Date:  2000-04       Impact factor: 8.739

Review 5.  Autophosphorylation: a salient feature of protein kinases.

Authors:  J A Smith; S H Francis; J D Corbin
Journal:  Mol Cell Biochem       Date:  1993-11       Impact factor: 3.396

6.  Molecular identification of a major palmitoylated erythrocyte membrane protein containing the src homology 3 motif.

Authors:  P Ruff; D W Speicher; A Husain-Chishti
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-01       Impact factor: 11.205

Review 7.  Hyaluronan: RHAMM mediated cell locomotion and signaling in tumorigenesis.

Authors:  C L Hall; E A Turley
Journal:  J Neurooncol       Date:  1995-12       Impact factor: 4.130

8.  Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src.

Authors:  C Seidel-Dugan; B E Meyer; S M Thomas; J S Brugge
Journal:  Mol Cell Biol       Date:  1992-04       Impact factor: 4.272
  8 in total

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