| Literature DB >> 21714976 |
Nikhom Wongsa1, Somdej Kanokmedhakul, Kwanjai Kanokmedhakul.
Abstract
Nine linear C23 and C21 acetogenins, named cananginones A-I (1-9), were isolated from stem bark of Miliusa velutina [corrected] . Their structures were established by spectroscopic methods. These compounds showed cytotoxicity against three cancer cell lines (KB, MCF7 and NCI-H187) with IC₅₀ values in the range 16.6-129.7 μM. Only 5 showed weak antimalarial activity against Plasmodium falciparum. In addition, 8 and 9 exhibited weak antifungal activity against Candida albicans.Entities:
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Year: 2011 PMID： 21714976 DOI： 10.1016/j.phytochem.2011.05.013
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072