BACKGROUND: Mutations in the maternally imprinted epsilon-sarcoglycan gene occur in 30%-50% of myoclonus-dystonia cases. Psychiatric symptoms, particularly obsessive-compulsive disorder, have been described in some patients. METHODS: We systematically reviewed 22 reports of psychiatric symptoms in myoclonus-dystonia, dividing individuals according to clinical and mutation status. RESULTS: Clinically manifesting mutation carriers demonstrated an excess of psychiatric disorders compared with nonmutation carriers (P < .001). No differences were seen between non-motor-manifesting carriers and nonmutation carriers with the exception of alcohol excess/dependence, higher in non-motor-manifesting carriers. CONCLUSIONS: The results confirm the association of epsilon-sarcoglycan gene mutations with psychiatric disease and suggest a possible separation of the motor and psychiatric effects.
BACKGROUND: Mutations in the maternally imprinted epsilon-sarcoglycan gene occur in 30%-50% of myoclonus-dystonia cases. Psychiatric symptoms, particularly obsessive-compulsive disorder, have been described in some patients. METHODS: We systematically reviewed 22 reports of psychiatric symptoms in myoclonus-dystonia, dividing individuals according to clinical and mutation status. RESULTS: Clinically manifesting mutation carriers demonstrated an excess of psychiatric disorders compared with nonmutation carriers (P < .001). No differences were seen between non-motor-manifesting carriers and nonmutation carriers with the exception of alcohol excess/dependence, higher in non-motor-manifesting carriers. CONCLUSIONS: The results confirm the association of epsilon-sarcoglycan gene mutations with psychiatric disease and suggest a possible separation of the motor and psychiatric effects.
Authors: M B Sheridan; A Bytyci Telegrafi; V Stinnett; C C Umeh; Z Mari; T M Dawson; J Bodurtha; D A S Batista Journal: Clin Genet Date: 2013-01-20 Impact factor: 4.438
Authors: Kathryn J Peall; Joke M Dijk; Rachel Saunders-Pullman; Yasmine E M Dreissen; Ilke van Loon; Danielle Cath; Manju A Kurian; Michael J Owen; Elisabeth M J Foncke; Huw R Morris; Thomas Gasser; Susan Bressman; Friedrich Asmus; Marina A J Tijssen Journal: Ann Clin Transl Neurol Date: 2015-11-20 Impact factor: 4.511
Authors: Kathryn J Peall; Daniel J Smith; Manju A Kurian; Mark Wardle; Adrian J Waite; Tammy Hedderly; Jean-Pierre Lin; Martin Smith; Alan Whone; Hardev Pall; Cathy White; Andrew Lux; Philip Jardine; Narinder Bajaj; Bryan Lynch; George Kirov; Sean O'Riordan; Michael Samuel; Timothy Lynch; Mary D King; Patrick F Chinnery; Thomas T Warner; Derek J Blake; Michael J Owen; Huw R Morris Journal: Brain Date: 2013-01 Impact factor: 13.501