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Literature DB >> 21713604

Therapeutic use of microRNAs in myocardial diseases.

Michael V G Latronico¹, Gianlugi Condorelli.

Abstract

The discovery of regulatory non-coding (nc) RNAs has opened a new world in cell biology. Within this class of ncRNAs, microRNAs (miRNAs) have been found to be involved in many cellular functions. Regarding the cardiovascular system, miRNAs regulate cardiomyocyte size and survival, the action potential, angiogenesis, mitochondrial function, and energetics. Moreover, misexpression of miRNAs has been linked to pathology, and altered levels of certain miRNAs even may cause disease. Thus, the manipulation of miRNAs, by affecting the biological processes in which they are implicated, may be used to improve cardiac function. The expression of microRNAs can be modulated through different approaches. This article reviews these issues in relation to the therapeutic potential of miRNAs for heart failure.

Entities: Disease

Mesh：

Substances：
MicroRNAs

Year: 2011 PMID： 21713604 DOI： 10.1007/s11897-011-0068-2

Source DB: PubMed Journal: Curr Heart Fail Rep ISSN： 1546-9530

33 in total

1. Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice.

Authors: David M Patrick; Rusty L Montgomery; Xiaoxia Qi; Susanna Obad; Sakari Kauppinen; Joseph A Hill; Eva van Rooij; Eric N Olson
Journal: J Clin Invest Date: 2010-10-18 Impact factor: 14.808

2. MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells.

Authors: Margaret S Ebert; Joel R Neilson; Phillip A Sharp
Journal: Nat Methods Date: 2007-08-12 Impact factor: 28.547

3. LNA-mediated microRNA silencing in non-human primates.

Authors: Joacim Elmén; Morten Lindow; Sylvia Schütz; Matthew Lawrence; Andreas Petri; Susanna Obad; Marie Lindholm; Maj Hedtjärn; Henrik Frydenlund Hansen; Urs Berger; Steven Gullans; Phil Kearney; Peter Sarnow; Ellen Marie Straarup; Sakari Kauppinen
Journal: Nature Date: 2008-03-26 Impact factor: 49.962

Review 4. MicroRNAs in cardiac apoptosis.

Authors: Peifeng Li
Journal: J Cardiovasc Transl Res Date: 2010-03-19 Impact factor: 4.132

5. Silencing of microRNA families by seed-targeting tiny LNAs.

Authors: Susanna Obad; Camila O dos Santos; Andreas Petri; Markus Heidenblad; Oliver Broom; Cristian Ruse; Cexiong Fu; Morten Lindow; Jan Stenvang; Ellen Marie Straarup; Henrik Frydenlund Hansen; Troels Koch; Darryl Pappin; Gregory J Hannon; Sakari Kauppinen
Journal: Nat Genet Date: 2011-03-20 Impact factor: 38.330

6. Efficacy of apolipoprotein B synthesis inhibition in subjects with mild-to-moderate hyperlipidaemia.

Authors: Fatima Akdim; Diane L Tribble; JoAnn D Flaim; Rosie Yu; John Su; Richard S Geary; Brenda F Baker; Rainard Fuhr; Mark K Wedel; John J P Kastelein
Journal: Eur Heart J Date: 2011-05-18 Impact factor: 29.983

Review 7. Pervasive roles of microRNAs in cardiovascular biology.

Authors: Eric M Small; Eric N Olson
Journal: Nature Date: 2011-01-20 Impact factor: 49.962

8. Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver.

Authors: Joacim Elmén; Morten Lindow; Asli Silahtaroglu; Mads Bak; Mette Christensen; Allan Lind-Thomsen; Maj Hedtjärn; Jens Bo Hansen; Henrik Frydenlund Hansen; Ellen Marie Straarup; Keith McCullagh; Phil Kearney; Sakari Kauppinen
Journal: Nucleic Acids Res Date: 2007-12-23 Impact factor: 16.971

9. A single anti-microRNA antisense oligodeoxyribonucleotide (AMO) targeting multiple microRNAs offers an improved approach for microRNA interference.

Authors: Yanjie Lu; Jiening Xiao; Huixian Lin; Yunlong Bai; Xiaobin Luo; Zhiguo Wang; Baofeng Yang
Journal: Nucleic Acids Res Date: 2009-01-09 Impact factor: 16.971

10. Potent inhibition of microRNA in vivo without degradation.

Authors: Scott Davis; Stephanie Propp; Susan M Freier; Laura E Jones; Martin J Serra; Garth Kinberger; Balkrishen Bhat; Eric E Swayze; C Frank Bennett; Christine Esau
Journal: Nucleic Acids Res Date: 2008-11-16 Impact factor: 16.971

15 in total

Review 1. Angiogenesis-regulating microRNAs and Ischemic Stroke.

Authors: Ke-Jie Yin; Milton Hamblin; Y Eugene Chen
Journal: Curr Vasc Pharmacol Date: 2015 Impact factor: 2.719

Review 2. MicroRNA208 family in cardiovascular diseases: therapeutic implication and potential biomarker.

Authors: Ying Huang; Jun Li
Journal: J Physiol Biochem Date: 2015-04-04 Impact factor: 4.158

Review 3. MicroRNA-based therapeutics in central nervous system injuries.

Authors: Ping Sun; Da Zhi Liu; Glen C Jickling; Frank R Sharp; Ke-Jie Yin
Journal: J Cereb Blood Flow Metab Date: 2018-04-30 Impact factor: 6.200

4. Cigarette smoking causes epigenetic changes associated with cardiorenal fibrosis.

Authors: Christopher A Drummond; Laura E Crotty Alexander; Steven T Haller; Xiaoming Fan; Jeffrey X Xie; David J Kennedy; Jiang Liu; Yanling Yan; Dawn-Alita Hernandez; Denzil P Mathew; Christopher J Cooper; Joseph I Shapiro; Jiang Tian
Journal: Physiol Genomics Date: 2016-10-27 Impact factor: 3.107

Review 5. Autophagy in cardiovascular biology.

Authors: Sergio Lavandero; Mario Chiong; Beverly A Rothermel; Joseph A Hill
Journal: J Clin Invest Date: 2015-01-02 Impact factor: 14.808

6. Na/K-ATPase signaling regulates collagen synthesis through microRNA-29b-3p in cardiac fibroblasts.

Authors: Christopher A Drummond; Michael C Hill; Huilin Shi; Xiaoming Fan; Jeffrey X Xie; Steven T Haller; David J Kennedy; Jiang Liu; Michael R Garrett; Zijian Xie; Christopher J Cooper; Joseph I Shapiro; Jiang Tian
Journal: Physiol Genomics Date: 2015-12-23 Impact factor: 3.107

10. Circulating levels of miR-133a predict the regression potential of left ventricular hypertrophy after valve replacement surgery in patients with aortic stenosis.

Authors: Raquel García; Ana V Villar; Manuel Cobo; Miguel Llano; Rafael Martín-Durán; María A Hurlé; J Francisco Nistal
Journal: J Am Heart Assoc Date: 2013-08-15 Impact factor: 5.501