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Literature DB >> 21713314

Zinc and zinc transporter regulation in pancreatic islets and the potential role of zinc in islet transplantation.

Mariea D Bosco¹, Daisy M Mohanasundaram, Chris J Drogemuller, Carol J Lang, Peter D Zalewski, P Toby Coates.

Abstract

The critical trace element zinc is essential for normal insulin production, and plays a central role in cellular protection against apoptosis and oxidative stress. The regulation of zinc within the pancreas and β-cells is controlled by the zinc transporter families ZnT and ZIP. Pancreatic islets display wide variability in the occurrence of these molecules. The zinc transporter, ZnT8 is an important target for autoimmunity in type 1 diabetes. Gene polymorphisms of this transporter confer sensitivity for immunosuppressive drugs used in islet transplantation. Understanding the biology of zinc transport within pancreatic islets will provide insight into the mechanisms of β-cell death, and may well reveal new pathways for improvement of diabetes therapy, including islet transplantation. This review discusses the possible roles of zinc in β-cell physiology with a special focus on islet transplantation.

Entities: Disease Gene

Mesh：

Substances：

Year: 2011 PMID： 21713314 PMCID： PMC3143541 DOI： 10.1900/RDS.2010.7.263

Source DB: PubMed Journal: Rev Diabet Stud ISSN： 1613-6071

106 in total

Review 1. Islet transplantation and antioxidant management: a comprehensive review.

Authors: Seyed Sajad Mohseni Salehi Monfared; Bagher Larijani; Mohammad Abdollahi
Journal: World J Gastroenterol Date: 2009-03-14 Impact factor: 5.742

2. Zinc bioavailability and homeostasis.

Authors: K Michael Hambidge; Leland V Miller; Jamie E Westcott; Xiaoyang Sheng; Nancy F Krebs
Journal: Am J Clin Nutr Date: 2010-03-03 Impact factor: 7.045

3. Three-dimensional structure of beta-cell-specific zinc transporter, ZnT-8, predicted from the type 2 diabetes-associated gene variant SLC30A8 R325W.

Authors: Rob Nm Weijers
Journal: Diabetol Metab Syndr Date: 2010-06-05 Impact factor: 3.320

4. The adaptive response to dietary zinc in mice involves the differential cellular localization and zinc regulation of the zinc transporters ZIP4 and ZIP5.

Authors: Jodi Dufner-Beattie; Yien-Ming Kuo; Jane Gitschier; Glen K Andrews
Journal: J Biol Chem Date: 2004-09-09 Impact factor: 5.157

Review 5. Zinc and selenium, site-specific versus general antioxidation.

Authors: W J Bettger
Journal: Can J Physiol Pharmacol Date: 1993-09 Impact factor: 2.273

6. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.

Authors: Richa Saxena; Benjamin F Voight; Valeriya Lyssenko; Noël P Burtt; Paul I W de Bakker; Hong Chen; Jeffrey J Roix; Sekar Kathiresan; Joel N Hirschhorn; Mark J Daly; Thomas E Hughes; Leif Groop; David Altshuler; Peter Almgren; Jose C Florez; Joanne Meyer; Kristin Ardlie; Kristina Bengtsson Boström; Bo Isomaa; Guillaume Lettre; Ulf Lindblad; Helen N Lyon; Olle Melander; Christopher Newton-Cheh; Peter Nilsson; Marju Orho-Melander; Lennart Råstam; Elizabeth K Speliotes; Marja-Riitta Taskinen; Tiinamaija Tuomi; Candace Guiducci; Anna Berglund; Joyce Carlson; Lauren Gianniny; Rachel Hackett; Liselotte Hall; Johan Holmkvist; Esa Laurila; Marketa Sjögren; Maria Sterner; Aarti Surti; Margareta Svensson; Malin Svensson; Ryan Tewhey; Brendan Blumenstiel; Melissa Parkin; Matthew Defelice; Rachel Barry; Wendy Brodeur; Jody Camarata; Nancy Chia; Mary Fava; John Gibbons; Bob Handsaker; Claire Healy; Kieu Nguyen; Casey Gates; Carrie Sougnez; Diane Gage; Marcia Nizzari; Stacey B Gabriel; Gung-Wei Chirn; Qicheng Ma; Hemang Parikh; Delwood Richardson; Darrell Ricke; Shaun Purcell
Journal: Science Date: 2007-04-26 Impact factor: 47.728

7. Insulin secretion defects of human type 2 diabetic islets are corrected in vitro by a new reactive oxygen species scavenger.

Authors: R Lupi; S Del Guerra; R Mancarella; M Novelli; L Valgimigli; G F Pedulli; M Paolini; A Soleti; F Filipponi; F Mosca; U Boggi; S Del Prato; P Masiello; P Marchetti
Journal: Diabetes Metab Date: 2007-07-09 Impact factor: 6.041

8. Intracellular transport of proinsulin in pancreatic beta-cells. Structural maturation probed by disulfide accessibility.

Authors: X F Huang; P Arvan
Journal: J Biol Chem Date: 1995-09-01 Impact factor: 5.157

9. Protective antioxidant and antiapoptotic effects of ZnCl2 in rat pancreatic islets cultured in low and high glucose concentrations.

Authors: Jessica Duprez; Leticia P Roma; Anne-Françoise Close; Jean-Christophe Jonas
Journal: PLoS One Date: 2012-10-03 Impact factor: 3.240

10. Insulin production hampered by intermittent hypoxia via impaired zinc homeostasis.

Authors: Eung-Kwon Pae; Gyuyoup Kim
Journal: PLoS One Date: 2014-02-25 Impact factor: 3.240

Zinc and zinc transporter regulation in pancreatic islets and the potential role of zinc in islet transplantation.

Review 1. Islet transplantation and antioxidant management: a comprehensive review.

2. Zinc bioavailability and homeostasis.

3. Three-dimensional structure of beta-cell-specific zinc transporter, ZnT-8, predicted from the type 2 diabetes-associated gene variant SLC30A8 R325W.

4. The adaptive response to dietary zinc in mice involves the differential cellular localization and zinc regulation of the zinc transporters ZIP4 and ZIP5.

Review 5. Zinc and selenium, site-specific versus general antioxidation.

6. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.

7. Insulin secretion defects of human type 2 diabetic islets are corrected in vitro by a new reactive oxygen species scavenger.

8. Intracellular transport of proinsulin in pancreatic beta-cells. Structural maturation probed by disulfide accessibility.

9. The influence of zinc supplementation on the pancreas of streptozotocin-diabetic rats.

Review 10. Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?

1. β Cells that Resist Immunological Attack Develop during Progression of Autoimmune Diabetes in NOD Mice.

2. NADPH oxidase-2 mediates zinc deficiency-induced oxidative stress and kidney damage.

3. Autocrine effect of Zn²⁺ on the glucose-stimulated insulin secretion.

4. Zinc deficiency alters the susceptibility of pancreatic beta cells (INS-1) to arsenic exposure.

5. A correlation study between multiple sclerosis and type 1 diabetes incidences and geochemical data in Europe.

6. Influence of vanadium-organic ligands treatment on selected metal levels in kidneys of STZ rats.

7. Zinc Homeostasis Alters Zinc Transporter Protein Expression in Vascular Endothelial and Smooth Muscle Cells.

Review 8. Zinc and insulin in pancreatic beta-cells.

9. Protective antioxidant and antiapoptotic effects of ZnCl2 in rat pancreatic islets cultured in low and high glucose concentrations.

10. Insulin production hampered by intermittent hypoxia via impaired zinc homeostasis.