Literature DB >> 21712851

Azathioprine-related myelosuppression in a patient homozygous for TPMT*3A.

Pooja Budhiraja1, Mordecai Popovtzer.   

Abstract

BACKGROUND: A 50-year-old man who had received a simultaneous pancreas and kidney transplant 9 years earlier developed pancytopenia 3 weeks after starting azathioprine therapy to treat worsening proteinuria suspected to be caused by sirolimus. INVESTIGATIONS: Laboratory tests, including complete blood counts, measurement of serum levels of vitamin B(12) and folate, liver function tests, virological assays, and thiopurine S-methyltransferase (TPMT) genotyping. DIAGNOSIS: Severe myelosuppression as a consequence of azathioprine therapy in a patient homozygous for the TPMT*3A allele. MANAGEMENT: Discontinuation of azathioprine, treatment with an erythropoiesis-stimulating agent, red blood cell transfusions, filgrastim (a granulocyte colony-stimulating factor analogue) and folic acid.

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Year:  2011        PMID： 21712851     DOI： 10.1038/nrneph.2011.74

Source DB:  PubMed          Journal:  Nat Rev Nephrol        ISSN： 1759-5061            Impact factor:   28.314


  30 in total

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