PURPOSE OF REVIEW: The interest and scope for research in the field of probiotics has significantly widened in recent years. This brief review covers the significant advances in the field of probiotics. RECENT FINDINGS: These include conclusive evidence for the benefits of probiotics in preventing all cause mortality and necrotizing enterocolitis (NEC) in preterm very low birth weight (VLBW) neonates, understanding the role of probiotics as vaccine adjuvants, and in modulating inflammatory bowel diseases, bowel cancer, type 1 diabetes mellitus, obesity, high cholesterol levels, and bacterial resistance. Other areas of progress include understanding the role of probiotics in oral health and ageing. SUMMARY: Current evidence will lead to routine probiotic supplementation to prevent all cause mortality and NEC in preterm VLBW neonates. Probiotics may also become novel agents as vaccine adjuvants, and in dealing with major public health issues such as obesity, type I diabetes mellitus, and poor oral health. Research in applications of probiotics in food products will rationalize product development, and health claims. As new frontiers continue to be explored the challenges to the basis of the hygiene hypothesis will influence further developments in the field of probiotics.
PURPOSE OF REVIEW: The interest and scope for research in the field of probiotics has significantly widened in recent years. This brief review covers the significant advances in the field of probiotics. RECENT FINDINGS: These include conclusive evidence for the benefits of probiotics in preventing all cause mortality and necrotizing enterocolitis (NEC) in preterm very low birth weight (VLBW) neonates, understanding the role of probiotics as vaccine adjuvants, and in modulating inflammatory bowel diseases, bowel cancer, type 1 diabetes mellitus, obesity, high cholesterol levels, and bacterial resistance. Other areas of progress include understanding the role of probiotics in oral health and ageing. SUMMARY: Current evidence will lead to routine probiotic supplementation to prevent all cause mortality and NEC in preterm VLBW neonates. Probiotics may also become novel agents as vaccine adjuvants, and in dealing with major public health issues such as obesity, type I diabetes mellitus, and poor oral health. Research in applications of probiotics in food products will rationalize product development, and health claims. As new frontiers continue to be explored the challenges to the basis of the hygiene hypothesis will influence further developments in the field of probiotics.
Authors: Gregor Reid; Nicholas Nduti; Wilbert Sybesma; Remco Kort; Tobias R Kollmann; Rod Adam; Hamadi Boga; Eric M Brown; Alexandra Einerhand; Hani El-Nezami; Gregory B Gloor; Irene I Kavere; Johanna Lindahl; Amee Manges; Wondu Mamo; Rocio Martin; Amy McMillan; Jael Obiero; Pamela A Ochieng'; Arnold Onyango; Stephen Rulisa; Eeva Salminen; Seppo Salminen; Antony Sije; Jonathan R Swann; William van Treuren; Daniel Waweru; Steve J Kemp Journal: Microbiome Date: 2014-04-16 Impact factor: 14.650
Authors: Bryon Petschow; Joël Doré; Patricia Hibberd; Timothy Dinan; Gregor Reid; Martin Blaser; Patrice D Cani; Fred H Degnan; Jane Foster; Glenn Gibson; John Hutton; Todd R Klaenhammer; Ruth Ley; Max Nieuwdorp; Bruno Pot; David Relman; Andrew Serazin; Mary Ellen Sanders Journal: Ann N Y Acad Sci Date: 2013-11-22 Impact factor: 5.691