Literature DB >> 2171199

Inhibition of endoproteolytic cleavage of cytomegalovirus (HCMV) glycoprotein B by palmitoyl-peptidyl-chloromethyl ketone.

K H Brücher1, W Garten, H D Klenk, E Shaw, K Radsak.   

Abstract

Endoproteolytic cleavage of glycoprotein B (gB) of human cytomegalovirus (HCMV) is inhibited by palmitoylated peptidyl-chloromethyl ketone (palFAKR-CEK) at concentrations above 30 microM. Inhibitor treatment of HCMV-infected human fibroblasts neither interfered with exposure of gB on the plasma membrane, detected by surface membrane immunostaining, nor reduced production of intracellular infectious viral progeny. Release of infectious virus, on the other hand, was impaired.

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Year:  1990        PMID： 2171199     DOI： 10.1016/0042-6822(90)90365-x

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  4 in total

1.  The beta3 subunit of the integrin alphaIIbbeta3 regulates alphaIIb-mediated outside-in signaling.

Authors:  Junling Liu; Carl W Jackson; Ralph A Gruppo; Lisa K Jennings; T Kent Gartner
Journal:  Blood       Date:  2005-02-08       Impact factor: 22.113

2.  Comparative sequence analysis of human cytomegalovirus strains.

Authors:  R Lehner; T Stamminger; M Mach
Journal:  J Clin Microbiol       Date:  1991-11       Impact factor: 5.948

3.  Antigenic domain 1 is required for oligomerization of human cytomegalovirus glycoprotein B.

Authors:  William J Britt; Michael A Jarvis; Derek D Drummond; Michael Mach
Journal:  J Virol       Date:  2005-04       Impact factor: 5.103

4.  Recognition of compartmentalized intracellular analogs of glycoprotein H of human cytomegalovirus.

Authors:  E Bogner; M Reschke; B Reis; E Reis; W Britt; K Radsak
Journal:  Arch Virol       Date:  1992       Impact factor: 2.574
  4 in total

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