Literature DB >> 21711159

Antiproliferative activity of novel derivative of thiopyran on breast and colon cancer lines and DNA binding.

Mehdi Rajabi1, Mohammad A Khalilzadeh, Jamshid Mehrzad.   

Abstract

Dimethyl-5-acetyl-4-methyl-6-(4-methylphenylimino)-6H-thiopyran-2,3-dicarboxylate (4) has been synthesized and its antiproliferative activity is reported here. Compound 4 inhibited the growth of human colon cancer cell line HCT-15 with an IC(50) value of 3.5 μM and of breast cancer cell line MCF-7 with an IC(50) value of 1.5 μM in a dose/time-dependent manner using a sulforhodamine B assay. Moreover, suppression of clonogenic activity occurred after exposure to 4 at a concentration of 4 μM for HCT-15 and 1.7 μM for MCF-7. The results also showed tumor cell invasion through matrigel and cell adhesion. The effect of ligand complexation on DNA structure led to overall affinity constant of K(4-DNA)=9.8×10(4) M(-1).

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Year:  2011        PMID： 21711159     DOI： 10.1089/dna.2011.1291

Source DB:  PubMed          Journal:  DNA Cell Biol        ISSN： 1044-5498            Impact factor:   3.311


  5 in total

1.  Plant hormones increase efficiency of reprogramming mouse somatic cells to induced pluripotent stem cells and reduce tumorigenicity.

Authors:  Ana Belén Alvarez Palomo; Samuel McLenachan; Jordi Requena Osete; Cristina Menchón; Carme Barrot; Fred Chen; Sergi Munné-Bosch; Michael J Edel
Journal:  Stem Cells Dev       Date:  2014-01-07       Impact factor: 3.272

2.  Antiproliferative activity of novel thiopyran analogs on MCF-7 breast and HCT-15 colon cancer cells: synthesis, cytotoxicity, cell cycle analysis, and DNA-binding.

Authors:  Fatemeh Tavakolinia; Tayebeh Baghipour; Zinatossadat Hossaini; Daryoush Zareyee; Mohammad A Khalilzadeh; Mehdi Rajabi
Journal:  Nucleic Acid Ther       Date:  2012-08-16       Impact factor: 5.486

3.  Molecular docking studies, biological evaluation and synthesis of novel 3-mercapto-1,2,4-triazole derivatives.

Authors:  Javad Ghanaat; Mohammad A Khalilzadeh; Daryoush Zareyee
Journal:  Mol Divers       Date:  2020-02-17       Impact factor: 2.943

4.  Hetero-Diels-Alder reactions of hetaryl and aryl thioketones with acetylenic dienophiles.

Authors:  Grzegorz Mlostoń; Paulina Grzelak; Maciej Mikina; Anthony Linden; Heinz Heimgartner
Journal:  Beilstein J Org Chem       Date:  2015-04-28       Impact factor: 2.883

5.  Apoptotic induction and inhibition of NF-κB signaling pathway in human prostatic cancer PC3 cells by natural compound 2,2'-oxybis (4-allyl-1-methoxybenzene), biseugenol B, from Litsea costalis: an in vitro study.

Authors:  Maryam Abbaspour Babaei; Hasniza Zaman Huri; Behnam Kamalidehghan; Swee Keong Yeap; Fatemeh Ahmadipour
Journal:  Onco Targets Ther       Date:  2017-01-10       Impact factor: 4.147
  5 in total

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