Literature DB >> 21710673

Deciding whether to go with the flow: evaluating the merits of flow reactors for synthesis.

Ryan L Hartman1, Jonathan P McMullen, Klavs F Jensen.   

Abstract

The fine chemicals and pharmaceutical industries are transforming how their products are manufactured, where economically favorable, from traditional batchwise processes to continuous flow. This evolution is impacting synthetic chemistry on all scales-from the laboratory to full production. This Review discusses the relative merits of batch and micro flow reactors for performing synthetic chemistry in the laboratory.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2011        PMID： 21710673     DOI： 10.1002/anie.201004637

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  62 in total

1.  Accelerating palladium-catalyzed C-F bond formation: use of a microflow packed-bed reactor.

Authors:  Timothy Noël; Thomas J Maimone; Stephen L Buchwald
Journal:  Angew Chem Int Ed Engl       Date:  2011-08-11       Impact factor: 15.336

2.  Accelerated gas-liquid visible light photoredox catalysis with continuous-flow photochemical microreactors.

Authors:  Natan J W Straathof; Yuanhai Su; Volker Hessel; Timothy Noël
Journal:  Nat Protoc       Date:  2015-12-03       Impact factor: 13.491

3.  Multistep continuous-flow synthesis of (R)- and (S)-rolipram using heterogeneous catalysts.

Authors:  Tetsu Tsubogo; Hidekazu Oyamada; Shū Kobayashi
Journal:  Nature       Date:  2015-04-16       Impact factor: 49.962

Review 4.  The past, present and potential for microfluidic reactor technology in chemical synthesis.

Authors:  Katherine S Elvira; Xavier Casadevall i Solvas; Robert C R Wootton; Andrew J deMello
Journal:  Nat Chem       Date:  2013-10-13       Impact factor: 24.427

5.  Continuous flow synthesis of ZSM-5 zeolite on the order of seconds.

Authors:  Zhendong Liu; Kotatsu Okabe; Chokkalingam Anand; Yasuo Yonezawa; Jie Zhu; Hiroki Yamada; Akira Endo; Yutaka Yanaba; Takeshi Yoshikawa; Koji Ohara; Tatsuya Okubo; Toru Wakihara
Journal:  Proc Natl Acad Sci U S A       Date:  2016-11-28       Impact factor: 11.205

6.  A flow-system array for the discovery and scale up of inorganic clusters.

Authors:  Craig J Richmond; Haralampos N Miras; Andreu Ruiz de la Oliva; Hongying Zang; Victor Sans; Leonid Paramonov; Charalampos Makatsoris; Ross Inglis; Euan K Brechin; De-Liang Long; Leroy Cronin
Journal:  Nat Chem       Date:  2012-11-18       Impact factor: 24.427

7.  Continuous flowing micro-reactor for aqueous reaction at temperature higher than 100 °C.

Authors:  Fei Xie; Baojun Wang; Wei Wang; Tian Dong; Jianhua Tong; Shanhong Xia; Wengang Wu; Zhihong Li
Journal:  Biomicrofluidics       Date:  2013-05-21       Impact factor: 2.800

8.  Dimethyl Dihydroacridines as Photocatalysts in Organocatalyzed Atom Transfer Radical Polymerization of Acrylate Monomers.

Authors:  Bonnie L Buss; Chern-Hooi Lim; Garret M Miyake
Journal:  Angew Chem Int Ed Engl       Date:  2020-01-21       Impact factor: 15.336

Review 9.  The Molecular Industrial Revolution: Automated Synthesis of Small Molecules.

Authors:  Melanie Trobe; Martin D Burke
Journal:  Angew Chem Int Ed Engl       Date:  2018-03-07       Impact factor: 15.336

10.  The assembly and use of continuous flow systems for chemical synthesis.

Authors:  Joshua Britton; Timothy F Jamison
Journal:  Nat Protoc       Date:  2017-10-26       Impact factor: 13.491
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