Literature DB >> 21709894

Synthesis and structure of all-syn-1,2,3,4-tetrafluorocyclohexane.

Alastair J Durie1, Alexandra M Z Slawin, Tomas Lebl, Peer Kirsch, David O'Hagan.   

Abstract

Preparation of the all-syn isomer of 1,2,3,4-tetrafluorocyclohexane is reported; X-ray structural studies shows a conformation with two of the C-F bonds oriented 1,3-diaxial to each other and (19)F-NMR reveals a through space diaxial (4)J(FF) coupling constant of 29 Hz.

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Year:  2011        PMID： 21709894     DOI： 10.1039/c1cc13016a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  7 in total

1.  All-cis 1,2,3,4,5,6-hexafluorocyclohexane is a facially polarized cyclohexane.

Authors:  Neil S Keddie; Alexandra M Z Slawin; Tomas Lebl; Douglas Philp; David O'Hagan
Journal:  Nat Chem       Date:  2015-04-13       Impact factor: 24.427

Review 2.  Rearrangements of organic peroxides and related processes.

Authors:  Ivan A Yaremenko; Vera A Vil'; Dmitry V Demchuk; Alexander O Terent'ev
Journal:  Beilstein J Org Chem       Date:  2016-08-03       Impact factor: 2.883

3.  Selectively fluorinated cyclohexane building blocks: Derivatives of carbonylated all-cis-3-phenyl-1,2,4,5-tetrafluorocyclohexane.

Authors:  Mohammed Salah Ayoup; David B Cordes; Alexandra M Z Slawin; David O'Hagan
Journal:  Beilstein J Org Chem       Date:  2015-12-21       Impact factor: 2.883

4.  Fluorinated cyclohexanes: Synthesis of amine building blocks of the all-cis 2,3,5,6-tetrafluorocyclohexylamine motif.

Authors:  Tetiana Bykova; Nawaf Al-Maharik; Alexandra M Z Slawin; David O'Hagan
Journal:  Beilstein J Org Chem       Date:  2017-04-19       Impact factor: 2.883

5.  Understanding the Conformational Behavior of Fluorinated Piperidines: The Origin of the Axial-F Preference.

Authors:  Zackaria Nairoukh; Felix Strieth-Kalthoff; Klaus Bergander; Frank Glorius
Journal:  Chemistry       Date:  2020-05-12       Impact factor: 5.236

6.  Turning the Other Cheek: Influence of the cis-Tetrafluorocyclohexyl Motif on Physicochemical and Metabolic Properties.

Authors:  Yong Wang; Wendy Lee; Yi-Chen Chen; Yuhui Zhou; Emile Plise; Madyson Migliozzi; James J Crawford
Journal:  ACS Med Chem Lett       Date:  2022-08-14       Impact factor: 4.632

Review 7.  Selective Arene Hydrogenation for Direct Access to Saturated Carbo- and Heterocycles.

Authors:  Mario P Wiesenfeldt; Zackaria Nairoukh; Toryn Dalton; Frank Glorius
Journal:  Angew Chem Int Ed Engl       Date:  2019-04-29       Impact factor: 15.336
  7 in total

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