BACKGROUND: Extremely abnormal prolongation of the electrocardiographic QT interval is associated with malignant ventricular arrhythmias and sudden cardiac death. However, the implications of variations in QT-interval length within normal limits for mortality in the general population are still unclear. METHODS: We performed a meta-analysis to investigate the relation of QT interval with mortality endpoints. Inverse-variance weighted random-effects models were used to summarize the relative risks across studies. Twenty-three observational studies were included. RESULTS: The pooled relative risk estimates comparing the highest with the lowest categories of QT-interval length were 1.35 (95% confidence interval = 1.24-1.46) for total mortality, 1.51 (1.29-1.78) for cardiovascular mortality, 1.71 (1.36-2.15) for coronary heart disease mortality, and 1.44 (1.01-2.04) for sudden cardiac death. A 50 milliseconds increase in QT interval was associated with a relative risk of 1.20 (1.15-1.26) for total mortality, 1.29 (1.15-1.46) for cardiovascular mortality, 1.49 (1.25-1.76) for coronary heart disease mortality, and 1.24 (0.97-1.60) for sudden cardiac death. CONCLUSIONS: We found consistent associations between prolonged QT interval and increased risk of total, cardiovascular, coronary, and sudden cardiac death. QT-interval length is a determinant of mortality in the general population.
BACKGROUND: Extremely abnormal prolongation of the electrocardiographic QT interval is associated with malignant ventricular arrhythmias and sudden cardiac death. However, the implications of variations in QT-interval length within normal limits for mortality in the general population are still unclear. METHODS: We performed a meta-analysis to investigate the relation of QT interval with mortality endpoints. Inverse-variance weighted random-effects models were used to summarize the relative risks across studies. Twenty-three observational studies were included. RESULTS: The pooled relative risk estimates comparing the highest with the lowest categories of QT-interval length were 1.35 (95% confidence interval = 1.24-1.46) for total mortality, 1.51 (1.29-1.78) for cardiovascular mortality, 1.71 (1.36-2.15) for coronary heart disease mortality, and 1.44 (1.01-2.04) for sudden cardiac death. A 50 milliseconds increase in QT interval was associated with a relative risk of 1.20 (1.15-1.26) for total mortality, 1.29 (1.15-1.46) for cardiovascular mortality, 1.49 (1.25-1.76) for coronary heart disease mortality, and 1.24 (0.97-1.60) for sudden cardiac death. CONCLUSIONS: We found consistent associations between prolonged QT interval and increased risk of total, cardiovascular, coronary, and sudden cardiac death. QT-interval length is a determinant of mortality in the general population.
Authors: J S Perkiömäki; L B Sourander; L Levomäki; I J Räihä; P Puukka; H V Huikuri Journal: Ann Noninvasive Electrocardiol Date: 2001-07 Impact factor: 1.468
Authors: Richard Kobza; Markus Roos; Bernhard Niggli; Roger Abächerli; Gianpiero A Lupi; Franz Frey; Johann Jakob Schmid; Paul Erne Journal: Heart Rhythm Date: 2009-01-16 Impact factor: 6.343
Authors: Ermeg L Akylbekova; Richard S Crow; William D Johnson; Sarah G Buxbaum; Stephanie Njemanze; Ervin Fox; Daniel F Sarpong; Herman A Taylor; Christopher Newton-Cheh Journal: Circ Arrhythm Electrophysiol Date: 2009-05-27
Authors: Pentti M Rautaharju; Zhu-ming Zhang; Richard E Gregg; Wesley K Haisty; Mara Z Vitolins; Anne B Curtis; James Warren; Milan B Horaĉek; Sophia H Zhou; Elsayed Z Soliman Journal: J Electrocardiol Date: 2013-07-01 Impact factor: 1.438
Authors: Katherine A Moon; Yiyi Zhang; Eliseo Guallar; Kevin A Francesconi; Walter Goessler; Jason G Umans; Lyle G Best; Barbara V Howard; Richard B Devereux; Peter M Okin; Ana Navas-Acien Journal: Environ Pollut Date: 2018-05-26 Impact factor: 8.071
Authors: Heather N Anderson; J Martijn Bos; Kristina H Haugaa; Bruce W Morlan; Robert F Tarrell; Pedro J Caraballo; Michael J Ackerman Journal: Pediatr Cardiol Date: 2015-04-07 Impact factor: 1.655
Authors: Atsushi Sorita; J Martijn Bos; Bruce W Morlan; Robert F Tarrell; Michael J Ackerman; Pedro J Caraballo Journal: J Am Med Inform Assoc Date: 2014-10-16 Impact factor: 4.497
Authors: Sofia Skampardoni; Dimitrios Poulikakos; Marek Malik; Darren Green; Philip A Kalra Journal: Nephrol Dial Transplant Date: 2019-07-01 Impact factor: 5.992