Literature DB >> 21709088

Determination of pentapeptide repeat units in Qnr proteins by the structure-based alignment approach.

Kwang Seung Park1, Jung Hun Lee, Da Un Jeong, Jae Jin Lee, Xing Wu, Byeong Chul Jeong, Choong-Min Kang, Sang Hee Lee.   

Abstract

The Qnr proteins belong to the pentapeptide repeat protein family. Despite each pentapeptide repeat unit being an important structural determinant, accurately determining pentapeptide repeat units in the Qnr proteins through sequence-based alignments has been challenging. In the present study, the pentapeptide repeat units of the nine representative Qnr proteins have been precisely determined via the structure-based alignment approach using homology modeling and superposition of their best models.

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Year:  2011        PMID： 21709088      PMCID： PMC3165317          DOI： 10.1128/AAC.00041-11

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  25 in total

1.  Structural and biochemical analysis of the pentapeptide repeat protein EfsQnr, a potent DNA gyrase inhibitor.

Authors:  Subray S Hegde; Matthew W Vetting; Lesley A Mitchenall; Anthony Maxwell; John S Blanchard
Journal:  Antimicrob Agents Chemother       Date:  2010-10-11       Impact factor: 5.191

2.  A novel family (QnrAS) of plasmid-mediated quinolone resistance determinant.

Authors:  Ha Ik Sun; Da Un Jeong; Jung Hun Lee; Xing Wu; Kwang Seung Park; Jae Jin Lee; Byeong Chul Jeong; Sang Hee Lee
Journal:  Int J Antimicrob Agents       Date:  2010-10-13       Impact factor: 5.283

3.  The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling.

Authors:  Konstantin Arnold; Lorenza Bordoli; Jürgen Kopp; Torsten Schwede
Journal:  Bioinformatics       Date:  2005-11-13       Impact factor: 6.937

4.  Evaluation of comparative protein modeling by MODELLER.

Authors:  A Sali; L Potterton; F Yuan; H van Vlijmen; M Karplus
Journal:  Proteins       Date:  1995-11

5.  Homology modeling and docking study of xanthine oxidase of Arthrobacter sp. XL26.

Authors:  R G Bodade; S D Beedkar; A V Manwar; C N Khobragade
Journal:  Int J Biol Macromol       Date:  2010-04-18       Impact factor: 6.953

6.  Mechanism of plasmid-mediated quinolone resistance.

Authors:  John H Tran; George A Jacoby
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-09       Impact factor: 11.205

7.  Mutational analysis of quinolone resistance in the plasmid-encoded pentapeptide repeat proteins QnrA, QnrB and QnrS.

Authors:  J M Rodríguez-Martínez; A Briales; C Velasco; M C Conejo; Luis Martínez-Martínez; A Pascual
Journal:  J Antimicrob Chemother       Date:  2009-04-08       Impact factor: 5.790

8.  qnrD, a novel gene conferring transferable quinolone resistance in Salmonella enterica serovar Kentucky and Bovismorbificans strains of human origin.

Authors:  L M Cavaco; H Hasman; S Xia; F M Aarestrup
Journal:  Antimicrob Agents Chemother       Date:  2008-11-24       Impact factor: 5.191

9.  QMEANclust: estimation of protein model quality by combining a composite scoring function with structural density information.

Authors:  Pascal Benkert; Torsten Schwede; Silvio Ce Tosatto
Journal:  BMC Struct Biol       Date:  2009-05-20

10.  Predictive analysis of transmissible quinolone resistance indicates Stenotrophomonas maltophilia as a potential source of a novel family of Qnr determinants.

Authors:  María B Sánchez; Alvaro Hernández; José M Rodríguez-Martínez; Luis Martínez-Martínez; José L Martínez
Journal:  BMC Microbiol       Date:  2008-09-16       Impact factor: 3.605
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  6 in total

1.  Phylogenetic analysis of chromosomally determined qnr and related proteins.

Authors:  George A Jacoby; David C Hooper
Journal:  Antimicrob Agents Chemother       Date:  2013-01-14       Impact factor: 5.191

2.  Cold shock induces chromosomal qnr in Vibrio species and plasmid-mediated qnrS1 in Escherichia coli.

Authors:  Hee-Chang Jang; Yin Wang; Chunhui Chen; Laura Vinué; George A Jacoby; David C Hooper
Journal:  Antimicrob Agents Chemother       Date:  2019-09-30       Impact factor: 5.191

Review 3.  Transferable Mechanisms of Quinolone Resistance from 1998 Onward.

Authors:  Joaquim Ruiz
Journal:  Clin Microbiol Rev       Date:  2019-08-14       Impact factor: 26.132

4.  QnrS1 structure-activity relationships.

Authors:  María M Tavío; George A Jacoby; David C Hooper
Journal:  J Antimicrob Chemother       Date:  2014-04-11       Impact factor: 5.790

5.  Mycobacterium fluoroquinolone resistance protein B, a novel small GTPase, is involved in the regulation of DNA gyrase and drug resistance.

Authors:  Jun Tao; Jiao Han; Hanyu Wu; Xinling Hu; Jiaoyu Deng; Joy Fleming; Anthony Maxwell; Lijun Bi; Kaixia Mi
Journal:  Nucleic Acids Res       Date:  2012-12-28       Impact factor: 16.971

6.  Mobilome and Resistome Reconstruction from Genomes Belonging to Members of the Bifidobacterium Genus.

Authors:  Walter Mancino; Gabriele Andrea Lugli; Douwe van Sinderen; Marco Ventura; Francesca Turroni
Journal:  Microorganisms       Date:  2019-12-02
  6 in total

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