Literature DB >> 21707502

Natural products: promising resources for cancer drug discovery.

Susmita Mondal1, Santu Bandyopadhyay, Mrinal K Ghosh, Sibabrata Mukhopadhyay, Siddhartha Roy, Chitra Mandal.   

Abstract

Natural products are important sources of anti-cancer lead molecules. Many successful anti-cancer drugs are natural products or their analogues. Many more are under clinical trials. The present review focuses on chemopreventive and anti-cancer activities of polar and non-polar extracts, semi purified fractions and pure molecules from terrestrial plants of India reported between 2005 and 2010 emphasizing possible mechanisms of action of pure molecules.

Entities:  

Mesh:

Substances:

Year:  2012        PMID: 21707502     DOI: 10.2174/187152012798764697

Source DB:  PubMed          Journal:  Anticancer Agents Med Chem        ISSN: 1871-5206            Impact factor:   2.505


  47 in total

1.  Ferutinin Induces Membrane Depolarization, Permeability Transition Pore Formation, and Respiration Uncoupling in Isolated Rat Liver Mitochondria by Stimulation of Ca2+-Permeability.

Authors:  Tatsiana Ilyich; Oksana Charishnikova; Szymon Sekowski; Maria Zamaraeva; Vitali Cheshchevik; Iosif Dremza; Nina Cheshchevik; Lyudmila Kiryukhina; Elena Lapshina; Ilya Zavodnik
Journal:  J Membr Biol       Date:  2018-03-28       Impact factor: 1.843

2.  Emodin induces apoptosis of human osteosarcoma cells via mitochondria- and endoplasmic reticulum stress-related pathways.

Authors:  Jinhe Ying; Huan Xu; Dhua Wu; Xiaoguang Wu
Journal:  Int J Clin Exp Pathol       Date:  2015-10-01

3.  Mahanine, a novel mitochondrial complex-III inhibitor induces G0/G1 arrest through redox alteration-mediated DNA damage response and regresses glioblastoma multiforme.

Authors:  Kaushik Bhattacharya; Arup K Bag; Rakshamani Tripathi; Suman K Samanta; Bikas C Pal; Chandrima Shaha; Chitra Mandal
Journal:  Am J Cancer Res       Date:  2014-11-19       Impact factor: 6.166

4.  Synergistic Anti-cancer Activity of MH-30 in a Murine Melanoma Model Treated With Cisplatin and its Alleviated Effects Against Cisplatin-induced Toxicity in Mice.

Authors:  Hae-Ran Park; Sung-Kee Jo; Hyang-Hee Cho; Uhee Jung
Journal:  In Vivo       Date:  2020 Jul-Aug       Impact factor: 2.155

5.  Acetyl-macrocalin B, an ent-kaurane diterpenoid, initiates apoptosis through the ROS-p38-caspase 9-dependent pathway and induces G2/M phase arrest via the Chk1/2-Cdc25C-Cdc2/cyclin B axis in non-small cell lung cancer.

Authors:  Jing-Nan Wang; Zhi-Rong Zhang; Yun Che; Zu-Yang Yuan; Zhi-Liang Lu; Yuan Li; Ning Li; Jun Wan; Han-Dong Sun; Nan Sun; Pema-Tenzin Puno; Jie He
Journal:  Cancer Biol Ther       Date:  2018-05-08       Impact factor: 4.742

6.  Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins.

Authors:  Yan Zhou; Qing-Hua Liu; Chun-Lei Liu; Li Lin
Journal:  Tumour Biol       Date:  2015-02-12

7.  Ligand binding to anti-cancer target CD44 investigated by molecular simulations.

Authors:  Tin Trung Nguyen; Duy Phuoc Tran; Zung Hoang; Paolo Carloni; Phuc Van Pham; Chuong Nguyen; Mai Suan Li
Journal:  J Mol Model       Date:  2016-06-24       Impact factor: 1.810

Review 8.  Cancer prevention with promising natural products: mechanisms of action and molecular targets.

Authors:  Poyil Pratheeshkumar; Chakkenchath Sreekala; Zhuo Zhang; Amit Budhraja; Songze Ding; Young-Ok Son; Xin Wang; Andrew Hitron; Kim Hyun-Jung; Lei Wang; Jeong-Chae Lee; Xianglin Shi
Journal:  Anticancer Agents Med Chem       Date:  2012-12       Impact factor: 2.505

9.  Salvianolic acid B induces apoptosis in human glioma U87 cells through p38-mediated ROS generation.

Authors:  Zi-shu Wang; Peng Luo; Shu-hui Dai; Zao-bin Liu; Xin-rui Zheng; Tao Chen
Journal:  Cell Mol Neurobiol       Date:  2013-07-11       Impact factor: 5.046

10.  Withaferin A induces cell death and differentiation in multiple myeloma cancer stem cells.

Authors:  Mark E Issa; Muriel Cuendet
Journal:  Medchemcomm       Date:  2016-11-17       Impact factor: 3.597

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.