Highly effective chiral phosphorus amidite-olefin ligands for palladium-catalyzed asymmetric allylic substitutions.

This paper describes the development of a type of novel P-olefin hybrid ligand by the incorporation of terminal olefins onto phosphorus amidite ligands for palladium-catalyzed asymmetric allylic alkylations of indoles and substitutions with amines to give the desired products in 70-97% yield with 91-98% ee.