M Auyeung1, T H Tsoi, W K Tang, C M Cheung, C N Lee, R Li, Eric Yeung. 1. Department of Medicine, Pamela Youde Nethersole Eastern Hospital, 3rd Lok Man Road, Chai Wan, Hong Kong Special Administrative Region, China. auyema@yahoo.com.hk
Abstract
OBJECTIVE: We studied the prevalence and related risk factors of impulse control disorders in Chinese Parkinson's disease patients. METHOD: We screened all non-demented Parkinson's disease patients attending our Parkinson's disease clinic from August 2009 to March 2010. The clinical characteristics of patients with impulse control disorders and those without were compared. RESULTS: Of the 213 PD subjects screened, 15 (7.0%) with impulse control disorders were identified. Fourteen of these subjects were on both a dopamine agonist and Levodopa, and one was on Levodopa alone. Of the fourteen subjects on both a dopamine agonist and Levodopa, eleven were on bromocriptine and Levodopa; 10.5% of the subjects exposed to bromocriptine had impulse control disorder. Upon multivariate analysis, dose of dopamine agonist used, young age at onset of Parkinson's disease and a history of anxiety or depression were independent predictors for developing impulse control disorders. CONCLUSIONS: 7% of our Chinese PD subjects had impulse control disorders. When young Parkinson's disease patients with a history of anxiety or depression are treated with high dose of DA, they are at risk of developing impulse control disorders.
OBJECTIVE: We studied the prevalence and related risk factors of impulse control disorders in Chinese Parkinson's diseasepatients. METHOD: We screened all non-demented Parkinson's diseasepatients attending our Parkinson's disease clinic from August 2009 to March 2010. The clinical characteristics of patients with impulse control disorders and those without were compared. RESULTS: Of the 213 PD subjects screened, 15 (7.0%) with impulse control disorders were identified. Fourteen of these subjects were on both a dopamine agonist and Levodopa, and one was on Levodopa alone. Of the fourteen subjects on both a dopamine agonist and Levodopa, eleven were on bromocriptine and Levodopa; 10.5% of the subjects exposed to bromocriptine had impulse control disorder. Upon multivariate analysis, dose of dopamine agonist used, young age at onset of Parkinson's disease and a history of anxiety or depression were independent predictors for developing impulse control disorders. CONCLUSIONS: 7% of our Chinese PD subjects had impulse control disorders. When young Parkinson's diseasepatients with a history of anxiety or depression are treated with high dose of DA, they are at risk of developing impulse control disorders.
Authors: Paloma Parra-Díaz; Juan Luis Chico-García; Álvaro Beltrán-Corbellini; Fernando Rodríguez-Jorge; Clara Lastras Fernández-Escandón; Araceli Alonso-Cánovas; Juan Carlos Martínez-Castrillo Journal: Mov Disord Clin Pract Date: 2020-12-21