| Literature DB >> 21705220 |
Pardeep Singh1, Shaveta Sachdeva, Raghu Raj, Vipan Kumar, Mohinder P Mahajan, Shereen Nasser, Livia Vivas, Jiri Gut, Phillip J Rosenthal, Tzu-Shean Feng, Kelly Chibale.
Abstract
3-Azido-, 3-amino- and 3-(1,2,3-triazol-1-yl)-β-lactams were synthesized and evaluated for their antiplasmodial activity against four strains of Plasmodium falciparum and KB cells for their cytotoxicity profiles. The presence of a cyclohexyl substituent at N-1 and a phenyl group on the triazole ring markedly improved the activity profiles of triazole-tethered β-lactam exhibiting IC(50) values of 1.13, 1.21 and 1.00 μM against 3D7, K1 and W2 strains respectively.Entities:
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Year: 2011 PMID： 21705220 DOI： 10.1016/j.bmcl.2011.05.119
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823