Literature DB >> 21704423

Evaluation of the efficacy of caffeine cessation, nortriptyline, and topiramate therapy in vestibular migraine and complex dizziness of unknown etiology.

Anthony A Mikulec1, Farhoud Faraji, Laurence J Kinsella.   

Abstract

OBJECTIVE: The aim of this study was to evaluate the efficacy of a therapeutic pathway for vestibular migraine (VM) and complex dizziness of undetermined etiology (CDUE) with caffeine cessation and pharmacotherapy. STUDY
DESIGN: This study is a retrospective chart review. INTERVENTION(S): Patients were recommended to stop intake of caffeine and other putative migraine-triggering agents. Pharmacotherapy was initiated with nortriptyline or topiramate if symptoms persisted despite diet modification. MAIN OUTCOME MEASURE: Self-reported dizziness is the main outcome measure.
RESULTS: Vestibular migraine and CDUE were considered contributing factors to dizziness in 34 and 10, respectively, of 156 patients. Fourteen percent of patients reported improvement in symptoms upon caffeine cessation, whereas 46% of patients reported a reduction in dizziness after nortriptyline therapy (P = .007). Topiramate reduced symptoms in 25% of patients. In total, 75% of VM patients and 56% of patients with CDUE received sufficient benefit from this therapeutic pathway to not progress to other treatments.
CONCLUSIONS: Vestibular migraine and CDUE can be treated effectively with a therapeutic pathway consisting of caffeine cessation followed by pharmacotherapy.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2011        PMID: 21704423     DOI: 10.1016/j.amjoto.2011.04.010

Source DB:  PubMed          Journal:  Am J Otolaryngol        ISSN: 0196-0709            Impact factor:   1.808


  8 in total

1.  Factors implicated in response to treatment/prognosis of vestibular migraine.

Authors:  James R Dornhoffer; Yuan F Liu; Lane Donaldson; Habib G Rizk
Journal:  Eur Arch Otorhinolaryngol       Date:  2020-05-24       Impact factor: 2.503

Review 2.  Vestibular migraine: the chameleon in vestibular disease.

Authors:  Minping Li; Xue Xu; Weiwei Qi; Yingyin Liang; Yongxin Huang; Haiwei Huang
Journal:  Neurol Sci       Date:  2021-03-05       Impact factor: 3.830

Review 3.  Current treatment options in vestibular migraine.

Authors:  Mark Obermann; Michael Strupp
Journal:  Front Neurol       Date:  2014-12-04       Impact factor: 4.003

Review 4.  Vestibular migraine: the most frequent entity of episodic vertigo.

Authors:  Marianne Dieterich; Mark Obermann; Nese Celebisoy
Journal:  J Neurol       Date:  2016-04-15       Impact factor: 4.849

Review 5.  Recent Advances in the Understanding of Vestibular Migraine.

Authors:  Jong-Hee Sohn
Journal:  Behav Neurol       Date:  2016-10-16       Impact factor: 3.342

Review 6.  The Ambiguous Role of Caffeine in Migraine Headache: From Trigger to Treatment.

Authors:  Magdalena Nowaczewska; Michał Wiciński; Wojciech Kaźmierczak
Journal:  Nutrients       Date:  2020-07-28       Impact factor: 5.717

Review 7.  The Treatment of Vestibular Migraine: A Narrative Review.

Authors:  Youjin Shen; Xiaokun Qi; Tingyu Wan
Journal:  Ann Indian Acad Neurol       Date:  2020-02-11       Impact factor: 1.383

8.  Effect of caffeine on cervical vestibular-evoked myogenic potential in healthy individuals.

Authors:  Ana Maria Almeida de Sousa; Fabio Akira Suzuki
Journal:  Braz J Otorhinolaryngol       Date:  2014 May-Jun
  8 in total

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