Literature DB >> 2170439

Differential suppression of interferon-gamma-induced Ia antigen expression on cultured rat astroglia and microglia by second messengers.

A Sasaki1, S W Levison, J P Ting.   

Abstract

The roles of intracellular second messengers in interferon-gamma (IFN-gamma)-induced Ia antigen (Ag) expression by astroglia and microglia were examined. Ia Ag on both glia types was induced by IFN-gamma. Reagents known to increase intracellular cAMP or activate intracellular protein kinase C (PKC) reduced IFN-gamma-induced Ia Ag expression by astroglia. In contrast, increasing intracellular cAMP had no suppressive effect on Ia Ag expression by microglia. These results indicate (1) cAMP and PKC negatively regulate IFN-gamma-induced Ia expression on astroglia, and (2) Ia expression is regulated differentially in astroglia vs. microglia. These findings may explain the frequent observation of Ia+ microglia (or macrophages) but not astroglia in various neurodegenerative diseases.

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Year:  1990        PMID： 2170439      PMCID： PMC7119474          DOI： 10.1016/0165-5728(90)90164-i

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  46 in total

1.  Alpah-adrenergic receptor modulation of beta-adrenergic, adenosine and prostaglandin E1 increased adenosine 3':5'-cyclic monophosphate levels in primary cultures of glia.

Authors:  K D McCarthy; J de Vellis
Journal:  J Cyclic Nucleotide Res       Date:  1978-02

2.  Immunohistochemical analysis of the rat central nervous system during experimental allergic encephalomyelitis, with special reference to Ia-positive cells with dendritic morphology.

Authors:  Y Matsumoto; N Hara; R Tanaka; M Fujiwara
Journal:  J Immunol       Date:  1986-05-15       Impact factor: 5.422

3.  Regulation of murine macrophage Ia antigen expression by an immune interferon-like lymphokine: inhibitory effect of endotoxin.

Authors:  P S Steeg; H M Johnson; J J Oppenheim
Journal:  J Immunol       Date:  1982-12       Impact factor: 5.422

4.  The immunopathology of experimental allergic encephalomyelitis. II. Endothelial cell Ia increases prior to inflammatory cell infiltration.

Authors:  R A Sobel; B W Blanchette; A K Bhan; R B Colvin
Journal:  J Immunol       Date:  1984-05       Impact factor: 5.422

5.  Evidence for a GTP-binding protein involved in interferon-gamma transduction signal.

Authors:  M Gariglio; A Franco; G Cavallo; S Landolfo
Journal:  J Interferon Res       Date:  1988-08

6.  Interferon-gamma and Ia antigen are present on astrocytes in active chronic multiple sclerosis lesions.

Authors:  U Traugott; P Lebon
Journal:  J Neurol Sci       Date:  1988-04       Impact factor: 3.181

7.  Down-regulation of protein kinase C is due to an increased rate of degradation.

Authors:  S Young; P J Parker; A Ullrich; S Stabel
Journal:  Biochem J       Date:  1987-06-15       Impact factor: 3.857

8.  Analysis of Ia induction on Lewis rat astrocytes in vitro by virus particles and bacterial adjuvants.

Authors:  P T Massa; V ter Meulen
Journal:  J Neuroimmunol       Date:  1987-01       Impact factor: 3.478

9.  MHC antigen expression on bulk isolated macrophage-microglia from newborn mouse brain: induction of Ia antigen expression by gamma-interferon.

Authors:  A Suzumura; S G Mezitis; N K Gonatas; D H Silberberg
Journal:  J Neuroimmunol       Date:  1987 Jul-Aug       Impact factor: 3.478

10.  Adoptive transfer of EAE-like lesions from rats with coronavirus-induced demyelinating encephalomyelitis.

Authors:  R Watanabe; H Wege; V ter Meulen
Journal:  Nature       Date:  1983 Sep 8-14       Impact factor: 49.962
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  4 in total

Review 1.  Current concepts in DRA gene regulation.

Authors:  J P Ting
Journal:  Immunol Res       Date:  1993       Impact factor: 2.829

2.  In vivo footprint analysis of the HLA-DRA gene promoter: cell-specific interaction at the octamer site and up-regulation of X box binding by interferon gamma.

Authors:  K L Wright; J P Ting
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-15       Impact factor: 11.205

3.  Differential tumor necrosis factor alpha expression by astrocytes from experimental allergic encephalomyelitis-susceptible and -resistant rat strains.

Authors:  I Y Chung; J G Norris; E N Benveniste
Journal:  J Exp Med       Date:  1991-04-01       Impact factor: 14.307

4.  Mouse hepatitis virus (MHV-4, JHM) blocks gamma-interferon-induced major histocompatibility complex class II antigen expression on murine cerebral endothelial cells.

Authors:  J Joseph; R L Knobler; F D Lublin; M N Hart
Journal:  J Neuroimmunol       Date:  1991-09       Impact factor: 3.478
  4 in total

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