| Literature DB >> 21704322 |
Olivier M Vanakker1, Kris De Coen, Laura Costrop, Paul J Coucke, Piet Vanhaesebrouck, Anne De Paepe.
Abstract
A neonate who received vitamin K (VK) supplementation then developed severe late-onset bleeding with abnormal prothrombin time and activated partial thromboplastine time. The bleeding was corrected after intravenous VK. Molecular analysis of the gamma-glutamylcarboxylase gene revealed a heterozygous single nucleotide polymorphism, which decreases carboxylase activity and induces VK-dependent coagulation deficiency.Entities:
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Year: 2011 PMID： 21704322 DOI： 10.1016/j.jpeds.2011.04.044
Source DB: PubMed Journal: J Pediatr ISSN： 0022-3476 Impact factor: 4.406