| Literature DB >> 21703685 |
Anne E Wiktor1, Daniel L Van Dyke, Janice M Hodnefield, Jeanette Eckel-Passow, Curtis A Hanson.
Abstract
To further investigate the potential clinical significance of Y chromosome loss as the sole bone marrow karyotype change, we studied 161 Mayo Clinic male patients with 75% or more metaphase cells with Y loss, and correlated the percent Y loss with age and hematopathologic review. In patients with a lymphoproliferative or plasma cell disorder, the negligible proportion of bone marrow involvement cannot account for the observed high proportion of -Y cells. In males with myeloid disease, Y loss appears to often represent the abnormal myeloid clone, which may also harbor acquired genetic changes that are not observed by conventional cytogenetic analysis.Entities:
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Year: 2011 PMID： 21703685 DOI： 10.1016/j.leukres.2011.05.002
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156