Literature DB >> 21703535

Intracellular trafficking of perforin: to thwart a killer.

Christopher Froelich1, Sunil Metkar.   

Abstract

How do killer cells restrain perforin, the most potent toxin known to biologists, at its point of synthesis in the endoplasmic reticulum, where conditions are ideal for its activation? In this issue of Immunity, Brennan et al. (2011) study its trafficking, offering insights into protective mechanisms.
Copyright © 2011 Elsevier Inc. All rights reserved.

Entities:  

Year:  2011        PMID： 21703535      PMCID： PMC3151722          DOI： 10.1016/j.immuni.2011.06.008

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  9 in total

1.  A common fold mediates vertebrate defense and bacterial attack.

Authors:  Carlos J Rosado; Ashley M Buckle; Ruby H P Law; Rebecca E Butcher; Wan-Ting Kan; Catherina H Bird; Kheng Ung; Kylie A Browne; Katherine Baran; Tanya A Bashtannyk-Puhalovich; Noel G Faux; Wilson Wong; Corrine J Porter; Robert N Pike; Andrew M Ellisdon; Mary C Pearce; Stephen P Bottomley; Jonas Emsley; A Ian Smith; Jamie Rossjohn; Elizabeth L Hartland; Ilia Voskoboinik; Joseph A Trapani; Phillip I Bird; Michelle A Dunstone; James C Whisstock
Journal:  Science       Date:  2007-08-23       Impact factor: 47.728

2.  Functional assessment of perforin C2 domain mutations illustrates the critical role for calcium-dependent lipid binding in perforin cytotoxic function.

Authors:  Ramon Urrea Moreno; Juana Gil; Carmen Rodriguez-Sainz; Elena Cela; Victor LaFay; Brian Oloizia; Andrew B Herr; Janos Sumegi; Michael B Jordan; Kimberly A Risma
Journal:  Blood       Date:  2008-10-16       Impact factor: 22.113

3.  Protection from endogenous perforin: glycans and the C terminus regulate exocytic trafficking in cytotoxic lymphocytes.

Authors:  Amelia J Brennan; Jenny Chia; Kylie A Browne; Annette Ciccone; Sarah Ellis; Jamie A Lopez; Olivia Susanto; Sandra Verschoor; Hideo Yagita; James C Whisstock; Joseph A Trapani; Ilia Voskoboinik
Journal:  Immunity       Date:  2011-06-09       Impact factor: 31.745

4.  Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain.

Authors:  R Uellner; M J Zvelebil; J Hopkins; J Jones; L K MacDougall; B P Morgan; E Podack; M D Waterfield; G M Griffiths
Journal:  EMBO J       Date:  1997-12-15       Impact factor: 11.598

5.  Cell-penetrating peptide induces leaky fusion of liposomes containing late endosome-specific anionic lipid.

Authors:  Sung-Tae Yang; Elena Zaitseva; Leonid V Chernomordik; Kamran Melikov
Journal:  Biophys J       Date:  2010-10-20       Impact factor: 4.033

Review 6.  Structure and mechanism in membrane trafficking.

Authors:  Frederick M Hughson; Karin M Reinisch
Journal:  Curr Opin Cell Biol       Date:  2010-04-24       Impact factor: 8.382

7.  Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491.

Authors:  Ilia Voskoboinik; Marie-Claude Thia; Jamie Fletcher; Annette Ciccone; Kylie Browne; Mark J Smyth; Joseph A Trapani
Journal:  J Biol Chem       Date:  2004-12-02       Impact factor: 5.157

8.  Rapid up-regulation and granule-independent transport of perforin to the immunological synapse define a novel mechanism of antigen-specific CD8+ T cell cytotoxic activity.

Authors:  George Makedonas; Pinaki P Banerjee; Rahul Pandey; Adam R Hersperger; Keri B Sanborn; Gareth A D Hardy; Jordan S Orange; Michael R Betts
Journal:  J Immunol       Date:  2009-05-01       Impact factor: 5.422

9.  The structural basis for membrane binding and pore formation by lymphocyte perforin.

Authors:  Ruby H P Law; Natalya Lukoyanova; Ilia Voskoboinik; Tom T Caradoc-Davies; Katherine Baran; Michelle A Dunstone; Michael E D'Angelo; Elena V Orlova; Fasséli Coulibaly; Sandra Verschoor; Kylie A Browne; Annette Ciccone; Michael J Kuiper; Phillip I Bird; Joseph A Trapani; Helen R Saibil; James C Whisstock
Journal:  Nature       Date:  2010-10-31       Impact factor: 49.962
  9 in total
  1 in total

1.  Ectopically expressed perforin-1 is proapoptotic in tumor cell lines by increasing caspase-3 activity and the nuclear translocation of cytochrome C.

Authors:  Li-Feng Wang; Fang Wang; Jun-Tang Li; Wei-Hong Wen; Jing Zhao; Lin-Tao Jia; Yan-Ling Meng; Yun-Xin Cao; Li-Bo Yao; Si-Yi Chen; Yan-Ming Xu; An-Gang Yang
Journal:  PLoS One       Date:  2012-07-19       Impact factor: 3.240
  1 in total

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