Gerda Rentschler1, K Broberg, T Lundh, S Skerfving. 1. Division of Occupational and Environmental Medicine, Lund University, SE-221 85 Lund, Sweden. Gerda.Rentschler@med.lu.se
Abstract
OBJECTIVE: Blood lead (B-Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P-Pb) is more adequate. METHODS: A long-term follow-up study of five cases of lead poisoning. P-Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled. RESULTS: P-Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower. CONCLUSION: P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.
OBJECTIVE: Blood lead (B-Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P-Pb) is more adequate. METHODS: A long-term follow-up study of five cases of lead poisoning. P-Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled. RESULTS:P-Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower. CONCLUSION:P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.
Authors: George B Cruz; Michelle A Vasquez; Ericka Cabañas; Jewel N Joseph; Jourvonn C Skeen; Kirsten P Lynch; Isra Ahmed; Eric B Khairi; Jalen R Bonitto; Evan G Clarke; Samantha Rubi; Nimra Hameed; Sukhpreet Kaur; Neena Mathew; Teddy F Dacius; Tokunbo J Jose; Gabriella Handford; Samuel Wolfe; Alex Feher; Kyle Tidwell; Jon Tobin; Enero Ugalde; Samantha Fee; Allison Choe; Katherine Gillenwater; Bilal Hindi; Shawna Pilout; Nick R Natale; Nick Domahoski; Molly H Kent; Joanna C Jacob; Kelly G Lambert; Lorenz S Neuwirth Journal: Adv Exp Med Biol Date: 2022 Impact factor: 3.650
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