| Literature DB >> 21701834 |
Gerda Rentschler1, K Broberg, T Lundh, S Skerfving.
Abstract
OBJECTIVE: Blood lead (B-Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P-Pb) is more adequate. <br> METHODS: A long-term follow-up study of five cases of lead poisoning. P-Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled. <br> RESULTS: P-Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower. <br> CONCLUSION: P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.Entities:
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Year: 2011 PMID: 21701834 PMCID: PMC3299963 DOI: 10.1007/s00420-011-0673-0
Source DB: PubMed Journal: Int Arch Occup Environ Health ISSN: 0340-0131 Impact factor: 3.015