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Literature DB >> 217017

L-aspartate: evidence for a role in cone photoreceptor synaptic transmission in the carp retina.

Abstract

A number of putative neurotransmitter substances and their antagonists were applied to the carp retina while intracellular recordings from L-type cone horizontal cells were made. Of all the substances tested, L-aspartate was found to be the most potent agent in depolarizing these horizontal cells in dark-adapted, partially light-adapted, and Co2+-treated retinas. Furthermore, DL-alpha-aminoadipate, an L-aspartate antagonist, blocked the effects of both the endogenous photoreceptor transmitter and exogenously applied L-aspartate on the horizontal cells. The results suggest that L-aspartate and the natural transmitter interact with the same population of postsynaptic receptors in the horizontal cell membrane.

Entities: Chemical Species

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Year: 1978 PMID： 217017 PMCID： PMC336294 DOI： 10.1073/pnas.75.10.5205

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

21 in total

1. Interactions of rod and cone signals in the mudpuppy retina.

Authors: G L Fain
Journal: J Physiol Date: 1975-11 Impact factor: 5.182

2. Muscarinic antagonists block cone to horizontal cell transmission in turtle retina.

Authors: H M Gerschenfeld; M Piccolino
Journal: Nature Date: 1977-07-21 Impact factor: 49.962

3. D-alpha-Aminoadipate as a selective antagonist of amino acid-induced and synaptic excitation of mammalian spinal neurones.

Authors: T J Biscoe; R H Evans; A A Francis; M R Martin; J C Watkins; J Davies; A Dray
Journal: Nature Date: 1977 Dec 22-29 Impact factor: 49.962

4. Autoradiography of some suspected neurotransmitter substances: GABA glycine, glutamic acid, histamine, dopamine, and L-dopa.

Authors: B Ehinger; B Falck
Journal: Brain Res Date: 1971-10-08 Impact factor: 3.252

5. Excitation of mammalian central neurones by acidic amino acids.

Authors: D R Curtis; A W Duggan; D Felix; G A Johnston; A K Teb ecis; J C Watkins
Journal: Brain Res Date: 1972-06-22 Impact factor: 3.252

6. Dark current and photocurrent in retinal rods.

Authors: W A Hagins; R D Penn; S Yoshikami
Journal: Biophys J Date: 1970-05 Impact factor: 4.033

Review 7. Amino acid transmitter substances in the vertebrate retina.

Authors: M J Neal
Journal: Gen Pharmacol Date: 1976-10

8. The actions of certain amino acids as neuronal excitants [proceedings].

Authors: J G Hall; H McLennan; H V Wheal
Journal: J Physiol Date: 1977-10 Impact factor: 5.182

9. [Reaction of cells--sources of S-potentials of turtle retina--to current conducted through the eye goblet].

Authors: Iu A Trifonov; A L Byzov
Journal: Biofizika Date: 1965

10. Effects of chemicals on receptors and horizontal cells in the retina.

Authors: M Murakami; K Otsu; T Otsuka
Journal: J Physiol Date: 1972-12 Impact factor: 5.182

23 in total

1. New approaches to ophthalmic electrodiagnosis by retinal oscillatory potential, drug-induced responses from retinal pigment epithelium and cone potential.

Authors: D Yonemura; K Kawasaki
Journal: Doc Ophthalmol Date: 1979-12-14 Impact factor: 2.379

6. Antagonism of excitatory amino acid-induced responses and of synaptic excitation in the isolated spinal cord of the frog.

Authors: R H Evans; A A Francis; K Hunt; D J Oakes; J C Watkins
Journal: Br J Pharmacol Date: 1979-12 Impact factor: 8.739

L-aspartate: evidence for a role in cone photoreceptor synaptic transmission in the carp retina.

1. Interactions of rod and cone signals in the mudpuppy retina.

2. Muscarinic antagonists block cone to horizontal cell transmission in turtle retina.

3. D-alpha-Aminoadipate as a selective antagonist of amino acid-induced and synaptic excitation of mammalian spinal neurones.

4. Autoradiography of some suspected neurotransmitter substances: GABA glycine, glutamic acid, histamine, dopamine, and L-dopa.

5. Excitation of mammalian central neurones by acidic amino acids.

6. Dark current and photocurrent in retinal rods.

Review 7. Amino acid transmitter substances in the vertebrate retina.

8. The actions of certain amino acids as neuronal excitants [proceedings].

9. [Reaction of cells--sources of S-potentials of turtle retina--to current conducted through the eye goblet].

10. Effects of chemicals on receptors and horizontal cells in the retina.

1. New approaches to ophthalmic electrodiagnosis by retinal oscillatory potential, drug-induced responses from retinal pigment epithelium and cone potential.

2. In-vivo labeling of (3H)D-aspartate uptake sites in monkey retina.

3. The release of gamma-aminobutyric acid from horizontal cells of the goldfish (Carassius auratus) retina.

4. Synaptic transmission at N-methyl-D-aspartate receptors in the proximal retina of the mudpuppy.

5. Ionotropic non-N-methyl-D-aspartate agonists induce retraction of dendritic spinules from retinal horizontal cells.

6. Antagonism of excitatory amino acid-induced responses and of synaptic excitation in the isolated spinal cord of the frog.

7. Stimulated release of 3H-glycine from retina.

8. D-aspartate potentiates the effects of L-glutamate on horizontal cells in goldfish retina.

9. Uptake of aspartic and glutamic acid by photoreceptors in goldfish retina.

10. Responses of solitary retinal horizontal cells from Carassius auratus to L-glutamate and related amino acids.