Literature DB >> 21701699

Gene therapy for myocardial infarction-associated congestive heart failure: how far have we got?

H Kirk Hammond1, Tong Tang.   

Abstract

With the advancement of vectors, delivery methods, and newly identified molecular targets, preclinical studies have shown that gene transfer is effective in improving left ventricular contractility and attenuating deleterious left ventricular remodeling in myocardial infarction-associated congestive heart failure (CHF). We are optimistic that these favorable effects will also be seen when tested in patients with CHF associated with myocardial infarction, as well as in patients with CHF from other etiologies. Gene therapy has the potential to be tailored to meet the needs of individual patients. Moreover, when used in conjunction with pharmacological and device management of the patient with CHF, it provides hope for a brighter future for the 23 million patients worldwide with this devastating disease.

Entities:  

Year:  2009        PMID： 21701699      PMCID： PMC3119547     

Source DB:  PubMed          Journal:  Dialog Cardiovasc Med        ISSN： 1272-9949


  23 in total

1.  Cardiac adenoviral S100A1 gene delivery rescues failing myocardium.

Authors:  Patrick Most; Sven T Pleger; Mirko Völkers; Beatrix Heidt; Melanie Boerries; Dieter Weichenhan; Eva Löffler; Paul M L Janssen; Andrea D Eckhart; Jeffrey Martini; Matthew L Williams; Hugo A Katus; Andrew Remppis; Walter J Koch
Journal:  J Clin Invest       Date:  2004-12       Impact factor: 14.808

2.  Myocardial gene transfer and long-term expression following intracoronary delivery of adeno-associated virus.

Authors:  Brian K Kaspar; David M Roth; N Chin Lai; Jeffrey D Drumm; Dawn A Erickson; M Dan McKirnan; H Kirk Hammond
Journal:  J Gene Med       Date:  2005-03       Impact factor: 4.565

Review 3.  The late phase of preconditioning and its natural clinical application--gene therapy.

Authors:  Roberto Bolli; Qian-Hong Li; Xian-Liang Tang; Yiru Guo; Yu-Ting Xuan; Gregg Rokosh; Buddhadeb Dawn
Journal:  Heart Fail Rev       Date:  2007-12       Impact factor: 4.214

4.  Modulation of ventricular function through gene transfer in vivo.

Authors:  R J Hajjar; U Schmidt; T Matsui; J L Guerrero; K H Lee; J K Gwathmey; G W Dec; M J Semigran; A Rosenzweig
Journal:  Proc Natl Acad Sci U S A       Date:  1998-04-28       Impact factor: 11.205

5.  In vivo ventricular gene delivery of a beta-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction.

Authors:  A S Shah; D C White; S Emani; A P Kypson; R E Lilly; K Wilson; D D Glower; R J Lefkowitz; W J Koch
Journal:  Circulation       Date:  2001-03-06       Impact factor: 29.690

6.  Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic functional heart failure rescue.

Authors:  Sven T Pleger; Patrick Most; Matthieu Boucher; Stephen Soltys; J Kurt Chuprun; Wiebke Pleger; Erhe Gao; Abhijit Dasgupta; Giuseppe Rengo; Andrew Remppis; Hugo A Katus; Andrea D Eckhart; Joseph E Rabinowitz; Walter J Koch
Journal:  Circulation       Date:  2007-04-30       Impact factor: 29.690

7.  Intracoronary adenovirus encoding adenylyl cyclase VI increases left ventricular function in heart failure.

Authors:  N Chin Lai; David M Roth; Mei Hua Gao; Tong Tang; Nancy Dalton; Yin Yin Lai; Matthew Spellman; Paul Clopton; H Kirk Hammond
Journal:  Circulation       Date:  2004-07-12       Impact factor: 29.690

8.  Cardiomyocyte cell cycle activation improves cardiac function after myocardial infarction.

Authors:  Rutger J Hassink; Kishore B Pasumarthi; Hidehiro Nakajima; Michael Rubart; Mark H Soonpaa; Aart Brutel de la Rivière; Pieter A Doevendans; Loren J Field
Journal:  Cardiovasc Res       Date:  2007-12-12       Impact factor: 10.787

9.  Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats.

Authors:  Yoshitaka Iwanaga; Masahiko Hoshijima; Yusu Gu; Mitsuo Iwatate; Thomas Dieterle; Yasuhiro Ikeda; Moto-o Date; Jacqueline Chrast; Masunori Matsuzaki; Kirk L Peterson; Kenneth R Chien; John Ross
Journal:  J Clin Invest       Date:  2004-03       Impact factor: 14.808

10.  Direct in vivo gene transfer into porcine myocardium using replication-deficient adenoviral vectors.

Authors:  B A French; W Mazur; R S Geske; R Bolli
Journal:  Circulation       Date:  1994-11       Impact factor: 29.690
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.