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Literature DB >> 21701512

Pro-senescence therapy for cancer treatment.

Caterina Nardella¹, John G Clohessy, Andrea Alimonti, Pier Paolo Pandolfi.

Abstract

Abundant evidence points to a crucial physiological role for cellular senescence in combating tumorigenesis. Thus, the engagement of senescence may represent a key component for therapeutic intervention in the eradication of cancer. In this Opinion article, we focus on concepts that are relevant to a pro-senescence approach to therapy and we propose potential therapeutic strategies that aim to enhance the pro-senescence response in tumours.

Entities: Disease

Mesh：

Substances：

Year: 2011 PMID： 21701512 DOI： 10.1038/nrc3057

Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716

104 in total

1. Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence.

Authors: Hui-Kuan Lin; Zhenbang Chen; Guocan Wang; Caterina Nardella; Szu-Wei Lee; Chia-Hsin Chan; Chan-Hsin Chan; Wei-Lei Yang; Jing Wang; Ainara Egia; Keiichi I Nakayama; Carlos Cordon-Cardo; Julie Teruya-Feldstein; Pier Paolo Pandolfi
Journal: Nature Date: 2010-03-18 Impact factor: 49.962

2. c-Myc inhibition negatively impacts lymphoma growth.

Authors: Ilsa Gomez-Curet; R Serene Perkins; Ryan Bennett; Katherine L Feidler; Stephen P Dunn; Leslie J Krueger
Journal: J Pediatr Surg Date: 2006-01 Impact factor: 2.545

3. Translational control of p27Kip1 accumulation during the cell cycle.

Authors: L Hengst; S I Reed
Journal: Science Date: 1996-03-29 Impact factor: 47.728

4. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

Authors: M Serrano; A W Lin; M E McCurrach; D Beach; S W Lowe
Journal: Cell Date: 1997-03-07 Impact factor: 41.582

5. Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner.

Authors: Min Sup Song; Arkaitz Carracedo; Leonardo Salmena; Su Jung Song; Ainara Egia; Marcos Malumbres; Pier Paolo Pandolfi
Journal: Cell Date: 2011-01-21 Impact factor: 41.582

Review 6. Breaking news: high-speed race ends in arrest--how oncogenes induce senescence.

Authors: Raffaella Di Micco; Marzia Fumagalli; Fabrizio d'Adda di Fagagna
Journal: Trends Cell Biol Date: 2007-11-05 Impact factor: 20.808

Review 7. Microenvironmental regulation of metastasis.

Authors: Johanna A Joyce; Jeffrey W Pollard
Journal: Nat Rev Cancer Date: 2008-03-12 Impact factor: 60.716

8. In vivo imaging of beta-galactosidase activity using far red fluorescent switch.

Authors: Ching-Hsuan Tung; Qing Zeng; Khalid Shah; Dong-Eog Kim; Dawid Schellingerhout; Ralph Weissleder
Journal: Cancer Res Date: 2004-03-01 Impact factor: 12.701

Review 9. The senescence-associated secretory phenotype: the dark side of tumor suppression.

Authors: Jean-Philippe Coppé; Pierre-Yves Desprez; Ana Krtolica; Judith Campisi
Journal: Annu Rev Pathol Date: 2010 Impact factor: 23.472

Review 10. Telomerase and cancer therapeutics.

Authors: Calvin B Harley
Journal: Nat Rev Cancer Date: 2008-03 Impact factor: 60.716

203 in total

1. Cellular senescence as a possible mechanism for halting progression of keloid lesions.

Authors: Shohreh Varmeh; Ainara Egia; Duncan McGrouther; Steven R Tahan; Ardeshir Bayat; Pier Paolo Pandolfi
Journal: Genes Cancer Date: 2011-11

Review 2. Regulation of senescence by microRNA biogenesis factors.

Authors: Kotb Abdelmohsen; Subramanya Srikantan; Min-Ju Kang; Myriam Gorospe
Journal: Ageing Res Rev Date: 2012-01-28 Impact factor: 10.895

3. A PTEN inhibitor displays preclinical activity against hepatocarcinoma cells.

Authors: Giuseppa Augello; Roberto Puleio; Maria Rita Emma; Antonella Cusimano; Guido R Loria; James A McCubrey; Giuseppe Montalto; Melchiorre Cervello
Journal: Cell Cycle Date: 2016 Impact factor: 4.534

Review 4. Turning off AKT: PHLPP as a drug target.

Authors: Alexandra C Newton; Lloyd C Trotman
Journal: Annu Rev Pharmacol Toxicol Date: 2014 Impact factor: 13.820

Review 5. Senescence at a glance.

Authors: Jeff S Pawlikowski; Peter D Adams; David M Nelson
Journal: J Cell Sci Date: 2013-08-22 Impact factor: 5.285

6. p53-Suppressed Oncogene TET1 Prevents Cellular Aging in Lung Cancer.

Authors: Piotr T Filipczak; Shuguang Leng; Carmen S Tellez; Kieu C Do; Marcie J Grimes; Cynthia L Thomas; Stephanie R Walton-Filipczak; Maria A Picchi; Steven A Belinsky
Journal: Cancer Res Date: 2019-01-08 Impact factor: 12.701

7. Identification of ribonucleotide reductase M2 as a potential target for pro-senescence therapy in epithelial ovarian cancer.

Authors: Katherine M Aird; Hua Li; Frances Xin; Panagiotis A Konstantinopoulos; Rugang Zhang
Journal: Cell Cycle Date: 2013-10-29 Impact factor: 4.534

8. Dachshund binds p53 to block the growth of lung adenocarcinoma cells.

Authors: Ke Chen; Kongming Wu; Shaoxin Cai; Wei Zhang; Jie Zhou; Jing Wang; Adam Ertel; Zhiping Li; Hallgeir Rui; Andrew Quong; Michael P Lisanti; Aydin Tozeren; Ceylan Tanes; Sankar Addya; Michael Gormley; Chenguang Wang; Steven B McMahon; Richard G Pestell
Journal: Cancer Res Date: 2013-03-14 Impact factor: 12.701

9. Synergistic interaction between cisplatin and PARP inhibitors in non-small cell lung cancer.

Authors: Judith Michels; Ilio Vitale; Laura Senovilla; David P Enot; Pauline Garcia; Delphine Lissa; Ken A Olaussen; Catherine Brenner; Jean-Charles Soria; Maria Castedo; Guido Kroemer
Journal: Cell Cycle Date: 2013-02-21 Impact factor: 4.534

10. p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion.

Authors: Aharon Helman; Agnes Klochendler; Narmen Azazmeh; Yael Gabai; Elad Horwitz; Shira Anzi; Avital Swisa; Reba Condiotti; Roy Z Granit; Yuval Nevo; Yaakov Fixler; Dorin Shreibman; Amit Zamir; Sharona Tornovsky-Babeay; Chunhua Dai; Benjamin Glaser; Alvin C Powers; A M James Shapiro; Mark A Magnuson; Yuval Dor; Ittai Ben-Porath
Journal: Nat Med Date: 2016-03-07 Impact factor: 53.440