RATIONALE: Gastroesophageal reflux (GER) is highly prevalent in patients with idiopathic pulmonary fibrosis (IPF). Chronic microaspiration secondary to GER may play a role in the pathogenesis and natural history of IPF. OBJECTIVES: To investigate the relationship between GER-related variables and survival time in patients with IPF. METHODS: Regression analysis was used to investigate the relationship between GER-related variables and survival time in a retrospectively identified cohort of patients with well-characterized IPF from two academic medical centers. MEASUREMENTS AND MAIN RESULTS: Two hundred four patients were identified for inclusion. GER-related variables were common in this cohort: reported symptoms of GER (34%), a history of GER disease (45%), reported use of GER medications (47%), and Nissen fundoplication (5%). These GER-related variables were significantly associated with longer survival time on unadjusted analysis. After adjustment, the use of GER medications was an independent predictor of longer survival time. In addition, the use of gastroesophageal reflux medications was associated with a lower radiologic fibrosis score. These findings were present regardless of center. CONCLUSIONS: The reported use of GER medications is associated with decreased radiologic fibrosis and is an independent predictor of longer survival time in patients with IPF. These findings further support the hypothesis that GER and chronic microaspiration may play important roles in the pathobiology of IPF.
RATIONALE: Gastroesophageal reflux (GER) is highly prevalent in patients with idiopathic pulmonary fibrosis (IPF). Chronic microaspiration secondary to GER may play a role in the pathogenesis and natural history of IPF. OBJECTIVES: To investigate the relationship between GER-related variables and survival time in patients with IPF. METHODS: Regression analysis was used to investigate the relationship between GER-related variables and survival time in a retrospectively identified cohort of patients with well-characterized IPF from two academic medical centers. MEASUREMENTS AND MAIN RESULTS: Two hundred four patients were identified for inclusion. GER-related variables were common in this cohort: reported symptoms of GER (34%), a history of GER disease (45%), reported use of GER medications (47%), and Nissen fundoplication (5%). These GER-related variables were significantly associated with longer survival time on unadjusted analysis. After adjustment, the use of GER medications was an independent predictor of longer survival time. In addition, the use of gastroesophageal reflux medications was associated with a lower radiologic fibrosis score. These findings were present regardless of center. CONCLUSIONS: The reported use of GER medications is associated with decreased radiologic fibrosis and is an independent predictor of longer survival time in patients with IPF. These findings further support the hypothesis that GER and chronic microaspiration may play important roles in the pathobiology of IPF.
Authors: Philip A Linden; Richard J Gilbert; Beow Y Yeap; Kathleen Boyle; Aaron Deykin; Michael T Jaklitsch; David J Sugarbaker; Raphael Bueno Journal: J Thorac Cardiovasc Surg Date: 2006-01-18 Impact factor: 5.209
Authors: Ganesh Raghu; Harold R Collard; Jim J Egan; Fernando J Martinez; Juergen Behr; Kevin K Brown; Thomas V Colby; Jean-François Cordier; Kevin R Flaherty; Joseph A Lasky; David A Lynch; Jay H Ryu; Jeffrey J Swigris; Athol U Wells; Julio Ancochea; Demosthenes Bouros; Carlos Carvalho; Ulrich Costabel; Masahito Ebina; David M Hansell; Takeshi Johkoh; Dong Soon Kim; Talmadge E King; Yasuhiro Kondoh; Jeffrey Myers; Nestor L Müller; Andrew G Nicholson; Luca Richeldi; Moisés Selman; Rosalind F Dudden; Barbara S Griss; Shandra L Protzko; Holger J Schünemann Journal: Am J Respir Crit Care Med Date: 2011-03-15 Impact factor: 21.405
Authors: Joyce S Lee; Harold R Collard; Ganesh Raghu; Matthew P Sweet; Steven R Hays; Guilherme M Campos; Jeffrey A Golden; Talmadge E King Journal: Am J Med Date: 2010-04 Impact factor: 4.965
Authors: G Raghu; T D Freudenberger; S Yang; J R Curtis; C Spada; J Hayes; J K Sillery; C E Pope; C A Pellegrini Journal: Eur Respir J Date: 2006-01 Impact factor: 16.671
Authors: Marco G Patti; Pietro Tedesco; Jeffrey Golden; Steven Hays; Charles Hoopes; Adam Meneghetti; Tanuja Damani; Lawrence W Way Journal: J Gastrointest Surg Date: 2005-11 Impact factor: 3.452
Authors: Edoardo Savarino; Marco Bazzica; Patrizia Zentilin; Daniel Pohl; Andrea Parodi; Giuseppe Cittadini; Simone Negrini; Francesco Indiveri; Radu Tutuian; Vincenzo Savarino; Massimo Ghio Journal: Am J Respir Crit Care Med Date: 2008-12-18 Impact factor: 21.405
Authors: Marco G Patti; Marcelo F Vela; David D Odell; Joel E Richter; P Marco Fisichella; Michael F Vaezi Journal: J Laparoendosc Adv Surg Tech A Date: 2016-05-24 Impact factor: 1.878
Authors: Marco E Allaix; P Marco Fisichella; Imre Noth; Bernardino M Mendez; Marco G Patti Journal: J Gastrointest Surg Date: 2013-04-25 Impact factor: 3.452