Literature DB >> 21700216

PKM2 and the tricky balance of growth and energy in cancer.

Andrew N Macintyre1, Jeffrey C Rathmell.   

Abstract

In this issue of Molecular Cell, Lv et al. (2011) identify a novel feedback mechanism in which increased glycolysis induces the acetylation and chaperone-mediated autophagic degradation of the glycolytic regulator PKM2, revealing a novel metabolic feedback loop that drives tumor growth.
Copyright © 2011 Elsevier Inc. All rights reserved.

Entities:  

Year:  2011        PMID： 21700216      PMCID： PMC3267323          DOI： 10.1016/j.molcel.2011.06.003

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  10 in total

Review 1.  The pleiotropic role of autophagy: from protein metabolism to bactericide.

Authors:  N Mizushima
Journal:  Cell Death Differ       Date:  2005-11       Impact factor: 15.828

Review 2.  Pyruvate kinase type M2 and its role in tumor growth and spreading.

Authors:  Sybille Mazurek; C Bruce Boschek; Ferdinand Hugo; Erich Eigenbrodt
Journal:  Semin Cancer Biol       Date:  2005-08       Impact factor: 15.707

3.  Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.

Authors:  Lei Lv; Dong Li; Di Zhao; Ruiting Lin; Yajing Chu; Heng Zhang; Zhengyu Zha; Ying Liu; Zi Li; Yanping Xu; Gang Wang; Yiran Huang; Yue Xiong; Kun-Liang Guan; Qun-Ying Lei
Journal:  Mol Cell       Date:  2011-06-24       Impact factor: 17.970

4.  Evidence for an alternative glycolytic pathway in rapidly proliferating cells.

Authors:  Matthew G Vander Heiden; Jason W Locasale; Kenneth D Swanson; Hadar Sharfi; Greg J Heffron; Daniel Amador-Noguez; Heather R Christofk; Gerhard Wagner; Joshua D Rabinowitz; John M Asara; Lewis C Cantley
Journal:  Science       Date:  2010-09-17       Impact factor: 47.728

5.  Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux.

Authors:  Qijun Wang; Yakun Zhang; Chen Yang; Hui Xiong; Yan Lin; Jun Yao; Hong Li; Lu Xie; Wei Zhao; Yufeng Yao; Zhi-Bin Ning; Rong Zeng; Yue Xiong; Kun-Liang Guan; Shimin Zhao; Guo-Ping Zhao
Journal:  Science       Date:  2010-02-19       Impact factor: 47.728

6.  Regulation of cellular metabolism by protein lysine acetylation.

Authors:  Shimin Zhao; Wei Xu; Wenqing Jiang; Wei Yu; Yan Lin; Tengfei Zhang; Jun Yao; Li Zhou; Yaxue Zeng; Hong Li; Yixue Li; Jiong Shi; Wenlin An; Susan M Hancock; Fuchu He; Lunxiu Qin; Jason Chin; Pengyuan Yang; Xian Chen; Qunying Lei; Yue Xiong; Kun-Liang Guan
Journal:  Science       Date:  2010-02-19       Impact factor: 47.728

7.  Uptake and degradation of glyceraldehyde-3-phosphate dehydrogenase by rat liver lysosomes.

Authors:  F Aniento; E Roche; A M Cuervo; E Knecht
Journal:  J Biol Chem       Date:  1993-05-15       Impact factor: 5.157

8.  The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.

Authors:  Heather R Christofk; Matthew G Vander Heiden; Marian H Harris; Arvind Ramanathan; Robert E Gerszten; Ru Wei; Mark D Fleming; Stuart L Schreiber; Lewis C Cantley
Journal:  Nature       Date:  2008-03-13       Impact factor: 49.962

9.  ATP-citrate lyase links cellular metabolism to histone acetylation.

Authors:  Kathryn E Wellen; Georgia Hatzivassiliou; Uma M Sachdeva; Thi V Bui; Justin R Cross; Craig B Thompson
Journal:  Science       Date:  2009-05-22       Impact factor: 47.728

10.  THE METABOLISM OF TUMORS IN THE BODY.

Authors:  O Warburg; F Wind; E Negelein
Journal:  J Gen Physiol       Date:  1927-03-07       Impact factor: 4.086
  10 in total
  28 in total

Review 1.  Targeting Cancer Metabolism and Current Anti-Cancer Drugs.

Authors:  Witchuda Sukjoi; Jarunya Ngamkham; Paul V Attwood; Sarawut Jitrapakdee
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

Review 2.  Protein-tyrosine phosphatase 1B substrates and metabolic regulation.

Authors:  Jesse Bakke; Fawaz G Haj
Journal:  Semin Cell Dev Biol       Date:  2014-09-28       Impact factor: 7.727

3.  Special nutrition in mouse developmental oocytes.

Authors:  Ling Yu; Shu-Fang Wang; Yuan-Qing Yao
Journal:  Exp Ther Med       Date:  2012-02-17       Impact factor: 2.447

4.  Succinyl-5-aminoimidazole-4-carboxamide-1-ribose 5'-Phosphate (SAICAR) Activates Pyruvate Kinase Isoform M2 (PKM2) in Its Dimeric Form.

Authors:  Ming Yan; Srinivas Chakravarthy; Joshua M Tokuda; Lois Pollack; Gregory D Bowman; Young-Sam Lee
Journal:  Biochemistry       Date:  2016-08-11       Impact factor: 3.162

Review 5.  Proteins moonlighting in tumor metabolism and epigenetics.

Authors:  Lei Lv; Qunying Lei
Journal:  Front Med       Date:  2021-01-02       Impact factor: 4.592

6.  Overexpression of pyruvate kinase M2 predicts a poor prognosis for patients with osteosarcoma.

Authors:  Zheng-Xuan Liu; Liang Hong; Song-Qing Fang; Guang-Hua Tan; Pei-Guan Huang; Zhi Zeng; Xue Xia; Xiao-Xu Wang
Journal:  Tumour Biol       Date:  2016-09-19

7.  Regulatory circuit of PKM2/NF-κB/miR-148a/152-modulated tumor angiogenesis and cancer progression.

Authors:  Q Xu; L-Z Liu; Y Yin; J He; Q Li; X Qian; Y You; Z Lu; S C Peiper; Y Shu; B-H Jiang
Journal:  Oncogene       Date:  2015-02-23       Impact factor: 9.867

8.  M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth.

Authors:  Marta Cortés-Cros; Christelle Hemmerlin; Stephane Ferretti; Juan Zhang; John S Gounarides; Hong Yin; Alban Muller; Anne Haberkorn; Patrick Chene; William R Sellers; Francesco Hofmann
Journal:  Proc Natl Acad Sci U S A       Date:  2012-12-24       Impact factor: 11.205

9.  PKM2 Promotes Cell Survival and Invasion Under Metabolic Stress by Enhancing Warburg Effect in Pancreatic Ductal Adenocarcinoma.

Authors:  Chenggang Li; Zhiming Zhao; Zhipeng Zhou; Rong Liu
Journal:  Dig Dis Sci       Date:  2015-10-24       Impact factor: 3.199

10.  Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation.

Authors:  Ahmed Bettaieb; Jesse Bakke; Naoto Nagata; Kosuke Matsuo; Yannan Xi; Siming Liu; Daniel AbouBechara; Ramzi Melhem; Kimber Stanhope; Bethany Cummings; James Graham; Andrew Bremer; Sheng Zhang; Costas A Lyssiotis; Zhong-Yin Zhang; Lewis C Cantley; Peter J Havel; Fawaz G Haj
Journal:  J Biol Chem       Date:  2013-05-02       Impact factor: 5.157
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